Institute of Tropical Medicine Antwerp
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Nonconventional and new methods in the diagnosis of tuberculosis: feasibility and applicability

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dc.contributor.author Palomino, J. C. en_US
dc.date.accessioned 2007-12-06T14:47:52Z
dc.date.available 2007-12-06T14:47:52Z
dc.date.issued 2005 en_US
dc.identifier.issn 0903-1936 en_US
dc.identifier.doi http://dx.doi.org/10.1183/09031936.05.00050305
dc.identifier.other ITG-MUA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-MYCOB en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1905
dc.description.abstract Tuberculosis (TB) remains one of the major causes of death from a single infectious agent worldwide. Of great concern for TB control is the emergence of drug resistance. Since there is no cure for some multidrug-resistant strains of Mycobacterium tuberculosis, there is concern that they may spread around the world, stressing the need for additional control measures, such as new diagnostics, better drugs for treatment, and a more effective vaccine. Pulmonary TB can be diagnosed by its symptoms, chest radiography, sputum smear microscopy and by cultivation of M. tuberculosis, which is considered as the gold standard. Recent advances in molecular biology and molecular epidemiology, and a better understanding of the molecular basis of drug resistance in TB, have provided new tools for rapid diagnosis; however, the high cost of most of these techniques, and their requirement for sophisticated equipment and skilled personnel have precluded their implementation on a routine basis, especially in low-income countries. Other nonconventional diagnostic approaches proposed include the search for biochemical markers, detection of immunological response and early detection of M. tuberculosis by methods other than colony counting. In the present article, some of these approaches will be reviewed and the feasibility for their implementation in diagnostic laboratories will be discussed. en_US
dc.language English en_US
dc.subject Bacterial diseases en_US
dc.subject Mycobacterial diseases en_US
dc.subject Tuberculosis en_US
dc.subject Laboratory diagnosis en_US
dc.subject Drug sensitivity testing en_US
dc.subject Feasibility en_US
dc.subject Laboratory techniques and procedures en_US
dc.subject Developing countries en_US
dc.title Nonconventional and new methods in the diagnosis of tuberculosis: feasibility and applicability en_US
dc.type Article en_US
dc.citation.jtitle European Respiratory Journal en_US
dc.citation.volume 26 en_US
dc.citation.pages 339-350 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/16055883
dc.citation.jabbreviation Eur Resp J en_US


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