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The impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa

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Show simple item record Ramjee, G. en_US Williams, B. en_US Gouws, E. en_US Van Dyck, E. en_US De Deken, B. en_US Abdool Karim, S. en_US 2007-12-06T14:48:02Z 2007-12-06T14:48:02Z 2005 en_US
dc.identifier.issn 1525-4135 en_US
dc.identifier.other ITG-M4A en_US
dc.identifier.other ITG-M5B en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-HIVSTD en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.description Not the final published version en_US
dc.description.abstract This study investigated the impact of prevalent and incident HSV-2 infection on the incidence of HIV-1 infection in a cohort of female commercial sex workers in KwaZulu-Natal, South Africa. Prior to a vaginal microbicide trial, 416 women were screened for antibodies to HIV-1 and herpes simplex virus-2 (HSV-2) infections and a questionnaire was used to establish behavioral, social, and demographic characteristics. A total of 187 HIV-1-seronegative women were followed up at monthly intervals when blood was drawn and used to detect HIV-1 and HSV-2 antibodies. The median duration of follow-up was 2.2 years. At screening 50% of the women were HIV-1 seropositive and 84% were HSV-2 seropositive. The hazards of HIV-1 among women who were HSV-2 seropositive or seronegative throughout, or among those who seroconverted during the study, were not significantly different. When HSV-2 seroconversion was analyzed as a time-dependent covariate, the hazard ratio for HIV-1 seroconversion was 6.0 (95% CI: 2.6-14.0) times greater among women with incident than among women with prevalent HSV-2 infections. Drawing on other recent studies these data suggest that incident HSV-2 infection increases the risk of HIV-1 infection; the effect wanes with time since infection; and the effect is significantly greater for men than it is for women. en_US
dc.language English en_US
dc.publisher Lippincott, Williams & Wilkins en_US
dc.subject Viral diseases en_US
dc.subject HIV-1 en_US
dc.subject Prostitutes en_US
dc.subject Sexually transmitted diseases en_US
dc.subject Genital ulcers en_US
dc.subject Herpes simplex virus type 2 en_US
dc.subject Incidence en_US
dc.subject Risk assessment en_US
dc.subject South Africa en_US
dc.title The impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa en_US
dc.type Article en_US
dc.citation.issue 3 en_US
dc.citation.jtitle Journal of Acquired Immune Deficiency Syndromes en_US
dc.citation.volume 39 en_US
dc.citation.pages 333-339 en_US Philadelphia en_US
dc.citation.jabbreviation J Acquir Immun Defic Syndr en_US

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