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Are the cellular immune responses of children and adults with Schistosoma mansoni infection intrinsically different? Cytokines produced ex vivo in response to antigens and mitogens

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dc.contributor.author Scott, J. T. en_US
dc.contributor.author Vereecken, K. en_US
dc.contributor.author Diakhaté, M. M. en_US
dc.contributor.author Vanagt, T. en_US
dc.contributor.author Sambou, V. en_US
dc.contributor.author Diop, M. en_US
dc.contributor.author Ly, A. en_US
dc.contributor.author Vercruysse, J. en_US
dc.contributor.author Gryseels, B. en_US
dc.contributor.author Kestens, L. en_US
dc.date.accessioned 2007-12-06T14:48:10Z
dc.date.available 2007-12-06T14:48:10Z
dc.date.issued 2004 en_US
dc.identifier.issn 0141-9838 en_US
dc.identifier.doi http://dx.doi.org/10.1111/j.0141-9838.2004.00680.x
dc.identifier.other ITG-M1B en_US
dc.identifier.other ITG-M2B en_US
dc.identifier.other ITG-P9A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-SCHISTO en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/1951
dc.description.abstract In recently exposed communities, intensity of schistosomiasis infection increases as children age and then drops again in adulthood, indicating that host maturity is an important aspect of resistance to schistosomiasis. We investigated whether the cellular immune response to the parasite was correlated with age in subjects with similar daily patterns of exposure, current intensities of infection and number of years of exposure. The cellular immune response of subjects with either 'low' (under 200 eggs per gram (EPG)) or 'high' (over 400 EPG) intensities of infection was investigated, in a recently established focus where subjects had similar histories of exposure and number of years of experience with Schistosoma mansoni. Subject's whole blood was cultured with adult worm antigen (AWA), a mixture of phytohaemagglutinin (PHA) and lipopolysaccharide (LPS), or left unstimulated, and culture supernatants were tested for IL-4, IL-5, IL-10 and IFN-gamma. Children and adults tended to respond differently to schistosome antigen. The most statistically significant illustration of this was the negative correlation between age and IL-5 produced by samples from people with low intensities of infection cultured with AWA (P < 0.003, P < 0.05 after Bonferroni correction). IL-10 produced by samples cultured with PHA and LPS was also notably lower in children than in adults, although not formally significant after Bonferroni correction. This indicates that it is possible for age, independently of intensity of infection or experience with the parasite, to influence the immune response to schistosomiasis. en_US
dc.language English en_US
dc.subject Helminthic diseases en_US
dc.subject Schistosoma mansoni en_US
dc.subject Immune response en_US
dc.subject Children en_US
dc.subject Adults en_US
dc.subject Cytokines en_US
dc.subject IFN-g en_US
dc.subject IL-10 en_US
dc.subject IL-4 en_US
dc.subject IL-5 en_US
dc.subject Senegal en_US
dc.subject Africa, West en_US
dc.title Are the cellular immune responses of children and adults with Schistosoma mansoni infection intrinsically different? Cytokines produced ex vivo in response to antigens and mitogens en_US
dc.type Article en_US
dc.citation.issue 1 en_US
dc.citation.jtitle Parasite Immunology en_US
dc.citation.volume 26 en_US
dc.citation.pages 29-36 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/15198643
dc.citation.jabbreviation Parasite Immunol en_US


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