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Endogenous reactivation and true treatment failure as causes of recurrent tuberculosis in a high incidence setting with a low HIV infection

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dc.contributor.author Shamputa, I. C. en_US
dc.contributor.author Van Deun, A. en_US
dc.contributor.author Salim, M. A. H. en_US
dc.contributor.author Hossain, M. A. en_US
dc.contributor.author Fissette, K. en_US
dc.contributor.author de Rijk, P. en_US
dc.contributor.author Rigouts, L. en_US
dc.contributor.author Portaels, F. en_US
dc.date.accessioned 2007-12-06T14:48:12Z
dc.date.available 2007-12-06T14:48:12Z
dc.date.issued 2007 en_US
dc.identifier.issn 1360-2276 en_US
dc.identifier.doi http://dx.doi.org/10.1111/j.1365-3156.2007.01840.x
dc.identifier.other ITG-M1B en_US
dc.identifier.other ITG-M2A en_US
dc.identifier.other ITG-M5B en_US
dc.identifier.other ITG-M6B en_US
dc.identifier.other ITG-M7A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-MYCOB en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.other FTB
dc.identifier.uri http://hdl.handle.net/10390/1957
dc.description The definitive version is available at www3.interscience.wiley.com
dc.description The definitive version is available at www3.interscience.wiley.com
dc.description.abstract OBJECTIVE: To determine the relative frequencies of reinfection vs. reactivation or treatment failure in patients from a high tuberculosis incidence setting with a low prevalence of HIV infection. METHOD: We performed DNA fingerprinting on serial isolates from one and multiple TB episodes from 97 retreatment patients; 35 patients had been previously cured, whereas 62 had not. RESULTS: DNA fingerprinting patterns of recurrence Mycobacterium tuberculosis isolates of 5 of the 35 previously cured patients did not match with those of the corresponding initial isolates, indicating reinfection. We did not document reinfection during treatment. Isolates from each of the remaining 30 previously cured patients had identical DNA fingerprinting results, indicating reactivation. DNA fingerprinting patterns of isolates from the 62 patients with persistently positive sputum smears were identical, suggesting treatment failure. CONCLUSION: These findings suggest that reinfection is not a common cause of relapse and treatment failure in this rural predominantly HIV-free population despite the high incidence of TB. en_US
dc.language English en_US
dc.publisher Blackwell Publishing
dc.publisher Blackwell Publishing
dc.subject Bacterial diseases en_US
dc.subject Tuberculosis en_US
dc.subject Recurrence en_US
dc.subject Treatment failure en_US
dc.subject Reinfection en_US
dc.subject DNA fingerprinting en_US
dc.title Endogenous reactivation and true treatment failure as causes of recurrent tuberculosis in a high incidence setting with a low HIV infection en_US
dc.type Article en_US
dc.citation.issue 6 en_US
dc.citation.jtitle Tropical Medicine and International Health en_US
dc.citation.volume 12 en_US
dc.citation.pages 700-708 en_US
dc.publisher.place Oxford
dc.publisher.place Oxford
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/17550467
dc.citation.jabbreviation Trop Med Int Health en_US


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