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Mycobacterium ulcerans disease

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dc.contributor.author van der Werf, T. S. en_US
dc.contributor.author Stienstra, Y. en_US
dc.contributor.author Johnson, R. C. en_US
dc.contributor.author Phillips, R. en_US
dc.contributor.author Adjei, O. en_US
dc.contributor.author Fleischer, B. en_US
dc.contributor.author Wansbrough-Jones, M. H. en_US
dc.contributor.author Johnson, P. D. R. en_US
dc.contributor.author Portaels, F. en_US
dc.contributor.author van der Graaf, W. T. A. en_US
dc.contributor.author Asiedu, K. en_US
dc.date.accessioned 2007-12-06T14:48:33Z
dc.date.available 2007-12-06T14:48:33Z
dc.date.issued 2005 en_US
dc.identifier.issn 0042-9686 en_US
dc.identifier.other ITG-M9A en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-MYCOB en_US
dc.identifier.other JIF en_US
dc.identifier.other FTA en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/2013
dc.description.abstract Mycobacterium ulcerans disease (Buruli ulcer) is an important health problem in several west African countries. It is prevalent in scattered foci around the world, predominantly in riverine areas with a humid, hot climate. We review the epidemiology, bacteriology, transmission, immunology, pathology, diagnosis and treatment of infections. M. ulcerans is an ubiquitous micro-organism and is harboured by fish, snails, and water insects. The mode of transmission is unknown. Lesions are most common on exposed parts of the body, particularly on the limbs. Spontaneous healing may occur. Many patients in endemic areas present late with advanced, severe lesions. BCG vaccination yields a limited, relatively short-lived, immune protection. Recommended treatment consists of surgical debridement, followed by skin grafting if necessary. Many patients have functional limitations after healing. Better understanding of disease transmission and pathogenesis is needed for improved control and prevention of Buruli ulcer. en_US
dc.language English en_US
dc.publisher World Health Organization en_US
dc.subject Bacterial diseases en_US
dc.subject Mycobacterial diseases en_US
dc.subject Mycobacterium ulcerans en_US
dc.subject Pathogenicity en_US
dc.subject Buruli ulcer en_US
dc.subject Epidemiology en_US
dc.subject Etiology en_US
dc.subject Transmission en_US
dc.subject Risk factors en_US
dc.subject Geographical distribution en_US
dc.subject Immunology en_US
dc.subject Differential diagnosis en_US
dc.subject Laboratory diagnosis en_US
dc.subject Clinical management en_US
dc.subject Review of the literature en_US
dc.title Mycobacterium ulcerans disease en_US
dc.type Article en_US
dc.citation.issue 10 en_US
dc.citation.jtitle Bulletin of the World Health Organization en_US
dc.citation.volume 83 en_US
dc.citation.pages 785-791 en_US
dc.publisher.place Geneva en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/16283056
dc.citation.jabbreviation Bull World Health Organ en_US


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