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Validation of candidate smear microscope quality indicators, extracted from tuberculosis laboratory registers

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Show simple item record Van Deun, A. en_US Zwahlen, M. en_US Bola, V. en_US Lebeke, R. en_US Bahati, E. en_US Lubamba, P. en_US Rieder, H. L. en_US 2007-12-06T14:48:40Z 2007-12-06T14:48:40Z 2007 en_US
dc.identifier.issn 1027-3719 en_US
dc.identifier.other ITG-M1A en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-MYCOB en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.description.abstract SETTING: Kinshasa Province, Democratic Republic of Congo. OBJECTIVE: To identify and validate register-based indicators of acid-fast bacilli (AFB) microscopy quality. DESIGN: Selection of laboratories based on reliability and variation in routine smear rechecking results. Calculation of relative sensitivity (RS) compared to recheckers and its correlation coefficient (R) with candidate indicators based on a fully probabilistic analysis incorporating vague prior information using WinBUGS. RESULTS: The proportion of positive follow-up smears correlated well (median R 0.81, 95% credibility interval [CI] 0.58-0.93), and the proportion of first smear-positive cases fairly (median R 0.70, 95% CI 0.38-0.89) with RS. The proportions of both positive suspect and low positive case smears showed poor correlations (median R 0.27 and -0.22, respectively, with ranges including zero). CONCLUSIONS: The proportion of positives in follow-up smears is the most promising indicator of AFB smear sensitivity, while the proportion of positive suspects may be more indicative of accessibility and suspect selection. Both can be obtained from simple reports, and should be used for internal and external monitoring and as guidance for supervision. As proportion of low positive suspect smears and consistency within case series are more difficult to interpret, they should be used only on-site by laboratory professionals. All indicators require more research to define their optimal range in various settings. en_US
dc.language English en_US
dc.publisher International Union Against Tuberculosis And Lung Disease
dc.subject Bacterial diseases en_US
dc.subject Tuberculosis en_US
dc.subject Laboratory diagnosis en_US
dc.subject Microscopy en_US
dc.subject Acid-fast bacilli en_US
dc.subject Evaluation en_US
dc.subject Indicators en_US
dc.subject Registration en_US
dc.subject Africa, Central en_US
dc.subject Congo-Kinshasa en_US
dc.title Validation of candidate smear microscope quality indicators, extracted from tuberculosis laboratory registers en_US
dc.type Article en_US
dc.citation.issue 3 en_US
dc.citation.jtitle International Journal of Tuberculosis and Lung Disease en_US
dc.citation.volume 11 en_US
dc.citation.pages 300-305 en_US Paris
dc.citation.jabbreviation Int J Tuberc Lung Dis en_US

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