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HTLV-1 infection is frequent among out-patients with pulmonary tuberculosis in northern Lima, Peru

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dc.contributor.author Verdonck, K. en_US
dc.contributor.author González, E. en_US
dc.contributor.author Henostroza, G. en_US
dc.contributor.author Nabeta, P. en_US
dc.contributor.author Llanos, F. en_US
dc.contributor.author Cornejo, H. en_US
dc.contributor.author Vanham, G. en_US
dc.contributor.author Seas, C. en_US
dc.contributor.author Gotuzzo, E. en_US
dc.date.accessioned 2007-12-06T14:48:49Z
dc.date.available 2007-12-06T14:48:49Z
dc.date.issued 2007 en_US
dc.identifier.issn 1027-3719 en_US
dc.identifier.other ITG-M1A en_US
dc.identifier.other ITG-M7A en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-VIROL en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/2052
dc.description.abstract SETTING: Tuberculosis (TB) and human T-lymphotropic virus 1 (HTLV-1) are frequent in Peru. The prevalence of HTLV-1 among Peruvian TB patients is unknown. OBJECTIVE: To determine the prevalence of HTLV-1, HTLV-2 and the human immunodeficiency virus (HIV) in out-patients with TB and to compare HTLV-1-infected patients with seronegative patients. DESIGN: Cross-sectional study including subjects aged 18-65 years diagnosed with smear-positive pulmonary TB at health centres in northern Lima from November 2004 to August 2005. HTLV and HIV screening was performed using enzyme-linked immunosorbent assay; HTLV-1 and HTLV-2 were confirmed using line immunoassay. RESULTS: There were 311 participants with a median age of 29 years; 173 (56%) were men. HTLV-1 prevalence was 5.8% (18/311, 95%CI 3.2-8.4) and HIV prevalence was 1.3% (4/304, 95%CI 0.4-3.3). HTLV-2 was not diagnosed. In comparison with HIV- and HTLV-seronegative patients, HTLV-1-infected subjects were older (median age 44 vs. 28, P < 0.001) and were more likely to have been born in the southern Andes (OR 4.4, 95%CI 1.6-11.9). They were also more likely to report a history of TB deaths in the family (OR 5.4, 95%CI 1.7-16.8) and had more sputum smear results graded as 3+ (OR 4.1, 95%CI 1.5-11.2). CONCLUSION: HTLV-1 screening among Peruvian TB patients is important. Because 3+ sputum smears are frequent and mortality is high among relatives, families of HTLV-1/TB-positive cases merit special attention. en_US
dc.language English en_US
dc.publisher International Union Against Tuberculosis And Lung Disease
dc.subject Bacterial diseases en_US
dc.subject Tuberculosis en_US
dc.subject Viral diseases en_US
dc.subject HIV en_US
dc.subject AIDS en_US
dc.subject HTLV-1 en_US
dc.subject Co-infections en_US
dc.subject Prevalence en_US
dc.subject Disease interactions en_US
dc.subject Peru en_US
dc.subject America, Latin en_US
dc.title HTLV-1 infection is frequent among out-patients with pulmonary tuberculosis in northern Lima, Peru en_US
dc.type Article en_US
dc.citation.issue 10 en_US
dc.citation.jtitle International Journal of Tuberculosis and Lung Disease en_US
dc.citation.volume 11 en_US
dc.citation.pages 1066-1072 en_US
dc.publisher.place Paris
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/17945062
dc.citation.jabbreviation Int J Tuberc Lung Dis en_US


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