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Association of atopy, allergic rhinoconjunctivitis, atopic dermatitis and intestinal helminth infections in Cuban children

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Show simple item record Wördemann, M. en_US Junco Diaz, R. en_US Menocal Heredia, L. en_US Collado Madurga, A. M. en_US Ruiz Espinosa, A. en_US Cordovi Prado, R. en_US Atencio Millan, I. en_US Escobedo, A. en_US Rojas Rivero, L. en_US Gryseels, B. en_US Bonet Gorbea, M. en_US Polman, K. en_US 2008-04-03T15:22:23Z 2008-04-03T15:22:23Z 2008
dc.identifier.issn 1360-2276
dc.identifier.other ITG-P1A en_US
dc.identifier.other ITG-D10A en_US
dc.identifier.other ITG-PLA en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-SCHISTO en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other UPD1 en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.other DIREC en_US
dc.identifier.other FTB en_US
dc.identifier.other DIRECT
dc.description The definitive version is available at
dc.description.abstract OBJECTIVE: To examine the relationship of past and current intestinal helminth infections with asthma, allergic rhinoconjunctivitis, atopic dermatitis and atopy. METHODS: Cross-sectional study of 1320 children aged 4-14 years from two Cuban municipalities. Helminth infections were determined by stool examination and parental questionnaire. Asthma, rhinoconjunctivitis and atopic dermatitis were diagnosed by International Study of Asthma and Allergies in Childhood questionnaire, asthma additionally by spirometry, atopy by skin prick testing. RESULTS: Questionnaire-based frequencies were 21% for asthma, 14% for allergic rhinoconjunctivitis and 8% for atopic dermatitis. According to spirometry, 4% had asthma; 20% had a positive skin prick test. A history of infection for Enterobius vermicularis was associated with increased risk of atopic dermatitis (OR 1.88, P = 0.001) and allergic rhinoconjunctivitis (OR 1.34, P = 0.046), and hookworm with increased risk of allergic rhinoconjunctivitis (OR 2.77, P = 0.021). A positive stool examination for Ascaris lumbricoides infection was negatively associated with atopic dermatitis (OR 0.22, P = 0.007). Asthma and atopy were unrelated to helminth infections. CONCLUSION: Current A. lumbricoides infection protects against atopic dermatitis in Cuban children, while past infection with E. vermicularis and hookworm are risk factors for allergic rhinoconjunctivitis and/or atopic dermatitis. Apparently, interactions differ depending on the type of helminth and atopic disease and on the time of helminth infestation. en_US
dc.language English en_US
dc.publisher Blackwell Publishing
dc.subject Helminthic diseases en_US
dc.subject Asthma en_US
dc.subject Atopy en_US
dc.subject Allergy en_US
dc.subject Rhinoconjunctivitis en_US
dc.subject Dermatitis en_US
dc.subject Disease interactions en_US
dc.subject Disease susceptibility en_US
dc.subject Disease resistance en_US
dc.subject Temporal sequence en_US
dc.subject Cuba en_US
dc.subject Caribbean en_US
dc.subject America, Latin en_US
dc.title Association of atopy, allergic rhinoconjunctivitis, atopic dermatitis and intestinal helminth infections in Cuban children en_US
dc.type Article en_US
dc.citation.issue 2 en_US
dc.citation.jtitle Tropical Medicine and International Health en_US
dc.citation.volume 13 en_US
dc.citation.pages 180-186 en_US Oxford
dc.citation.jabbreviation Trop Med Int Health en_US

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