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Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-I Y86) and amodiaquine resistance in Burkina Faso

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dc.contributor.author Tinto, H. en_US
dc.contributor.author Guekoun, L. en_US
dc.contributor.author Zongo, I. en_US
dc.contributor.author Guiguemdé, R. T. en_US
dc.contributor.author D'Alessandro, U. en_US
dc.contributor.author Ouédraogo, J. B. en_US
dc.date.accessioned 2008-04-07T11:35:30Z
dc.date.available 2008-04-07T11:35:30Z
dc.date.issued 2008
dc.identifier.issn 1360-2276
dc.identifier.doi http://dx.doi.org/10.1111/j.1365-3156.2007.01995.x
dc.identifier.other ITG-P5A en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-MALAR en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other UPD1 en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.other FTB en_US
dc.identifier.uri http://hdl.handle.net/10390/2226
dc.description The definitive version is available at www3.interscience.wiley.com
dc.description.abstract We investigated the relationship between the two main molecular markers for chloroquine resistance (Pfcrt T76 and Pfmdr-1 Y86) and the clinical efficacy of amodiaquine in Burkina Faso. Before treatment, the prevalence of Pfcrt T76, Pfmdr-1 Y86 or both mutations in the same infection was significantly higher in patients who experienced a recrudescence than in those who successfully responded to the treatment. Therefore, these two molecular markers could be useful in monitoring amodiaquine resistance, particularly in countries where this drug is used in combination with artesunate as first- or second-line treatment. en_US
dc.language English en_US
dc.publisher Blackwell Publishing
dc.subject Protozoal diseases en_US
dc.subject Malaria en_US
dc.subject Drug resistance en_US
dc.subject Molecular markers en_US
dc.subject Pfcrt en_US
dc.subject Pfmdr-1 en_US
dc.subject Chloroquine en_US
dc.subject Amodiaquine en_US
dc.subject Interactions en_US
dc.subject Burkina Faso en_US
dc.subject Africa, West en_US
dc.title Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-I Y86) and amodiaquine resistance in Burkina Faso en_US
dc.type Article en_US
dc.citation.issue 2 en_US
dc.citation.jtitle Tropical Medicine and International Health en_US
dc.citation.volume 13 en_US
dc.citation.pages 238-240 en_US
dc.publisher.place Oxford
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/18304270
dc.citation.jabbreviation Trop Med Int Health en_US


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