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A neglected disease of humans: a new focus of visceral leishmaniasis in Bakool, Somalia

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dc.contributor.author Marlet, M. V. L. en_US
dc.contributor.author Wuillaume, F. en_US
dc.contributor.author Jacquet, D. en_US
dc.contributor.author Quispe, K. W. en_US
dc.contributor.author Dujardin, J. C. en_US
dc.contributor.author Boelaert, M. en_US
dc.date.accessioned 2007-12-06T14:33:51Z
dc.date.available 2007-12-06T14:33:51Z
dc.date.issued 2003 en_US
dc.identifier.issn 0035-9203 en_US
dc.identifier.doi http://dx.doi.org/10.1016/S0035-9203(03)80099-8
dc.identifier.other ITG-P3B en_US
dc.identifier.other ITG-P4B en_US
dc.identifier.other ITG-P5A en_US
dc.identifier.other ITG-HLA en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-PROTO en_US
dc.identifier.other HEALTH en_US
dc.identifier.other U-EPID en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other MULTI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/224
dc.description.abstract Visceral leishmaniasis (VL) was observed in children in Bakool region, Somalia, an area where VL has not been reported before. We describe the extent of the problem in this war- and famine-stricken area. A retrospective analysis was done of all cases admitted to a VL treatment centre between July 2000 and August 2001. Patients with longstanding fever, splenomegaly and a positive direct agglutination test (DAT; titre > 1:3200) were treated as suspected VL cases. A rapid epidemiological and entomological assessment was performed in the area. Species identification was attempted from blood samples by polymerase chain reaction-restriction fragment length polymorphism analysis of cysteine proteinase B genes. In 1 year, 230 serologically-positive cases were diagnosed as VL, and response to therapy was good in 91.6% of the 225 treated with sodium stibogluconate. Parasitological confirmation was attempted and obtained in 2 cases. Parasites were found to be most similar to Sudanese and Ethiopian reference strains of the Leishmania donovani complex. In a serological survey of 161 healthy displaced persons, 15% were positive by the leishmanin skin test and 3 (2%) were positive by the DAT. The sandfly captures showed Phlebotomus martini and P. vansomerenae. VL seems to be a longstanding and serious health problem in Bakool region. Food insecurity might have contributed to the emergence and detection of VL in this area. en_US
dc.language English en_US
dc.publisher Elsevier
dc.subject Protozoal diseases en_US
dc.subject Leishmaniasis en_US
dc.subject Visceral en_US
dc.subject Kala azar en_US
dc.subject Leishmania donovani en_US
dc.subject Epidemiology en_US
dc.subject Outbreaks en_US
dc.subject Somalia en_US
dc.subject Africa, East en_US
dc.title A neglected disease of humans: a new focus of visceral leishmaniasis in Bakool, Somalia en_US
dc.type Article en_US
dc.citation.issue 6 en_US
dc.citation.jtitle Transactions of the Royal Society of Tropical Medicine and Hygiene en_US
dc.citation.volume 97 en_US
dc.citation.pages 667-671 en_US
dc.publisher.place Amsterdam
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/16117959
dc.identifier.url http://www.elsevier.com/locate/trstmh
dc.citation.jabbreviation Trans R Soc Trop Med Hyg en_US


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