Institute of Tropical Medicine Antwerp
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Reducing the burden of malaria in pregnancy by preventive strategies

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dc.contributor.author Menéndez, C. en_US
dc.contributor.author D'Alessandro, U. en_US
dc.contributor.author ter Kuile, F. O. en_US
dc.date.accessioned 2007-12-06T14:33:51Z
dc.date.available 2007-12-06T14:33:51Z
dc.date.issued 2007 en_US
dc.identifier.issn 1473-3099 en_US
dc.identifier.doi http://dx.doi.org/10.1016/S1473-3099(07)70024-5
dc.identifier.other ITG-P2A en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-MALAR en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/225
dc.description.abstract Malaria is one of the most common and preventable causes of adverse birth outcomes. In Africa, important progress has been made in the past decade with the introduction of a preventive strategy for malaria in pregnancy consisting of intermittent preventive treatment in pregnancy (IPTp) and insecticide-treated nets, yet their coverage is still unacceptably low and malaria continues to demand a huge toll on pregnant women and their newborn babies. Increasing the frequency of dosing of IPTp with sulfadoxine-pyrimethamine might provide temporary respite, but increasing resistance to sulfadoxine-pyrimethamine makes research into safe, efficacious, and affordable alternatives for IPTp one of the highest priorities for the control of malaria in pregnancy. A number of promising alternatives are, or will soon be, available that need to be evaluated as IPTp after their safety and pharmacokinetics in pregnancy have first been assessed in parasitaemic women. Little is known about appropriate control strategies in Asia and Latin America for Plasmodium falciparum and Plasmodium vivax malaria in pregnancy, which in most countries rely on responsive case management approaches. The role of case management based on proactive screening for malaria infection of women attending antenatal care or preventive approaches with insecticide-treated nets or IPTp are urgently needed. To achieve these objectives, multicentre and multidisciplinary approaches are required across the range of malaria transmission settings that include assessment of immunological effect of successful preventions, the perceptions and acceptability of different preventive approaches, and their cost-effectiveness. en_US
dc.language English en_US
dc.subject Protozoal diseases en_US
dc.subject Malaria en_US
dc.subject Plasmodium falciparum en_US
dc.subject Plasmodium vivax en_US
dc.subject Pregnancy en_US
dc.subject Disease prevention en_US
dc.subject Intermittent treatment en_US
dc.subject Sulfadoxine-pyrimethamine en_US
dc.subject Drug resistance en_US
dc.subject Screening en_US
dc.subject Prenatal health care en_US
dc.subject Impregnated bednets en_US
dc.subject Research needs en_US
dc.subject Perceptions en_US
dc.subject Acceptability en_US
dc.subject Cost-effectiveness en_US
dc.subject Africa en_US
dc.subject America, Latin en_US
dc.subject Asia en_US
dc.title Reducing the burden of malaria in pregnancy by preventive strategies en_US
dc.type Article en_US
dc.citation.issue 2 en_US
dc.citation.jtitle Lancet Infectious Diseases en_US
dc.citation.volume 7 en_US
dc.citation.pages 126-135 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/17251083
dc.citation.jabbreviation Lancet Infect Dis en_US


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