Institute of Tropical Medicine Antwerp
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Titrating Theileria parva: single stocks against combination of stocks

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dc.contributor.author Speybroeck, N. en_US
dc.contributor.author Marcotty, T. en_US
dc.contributor.author Aerts, M. en_US
dc.contributor.author Dolan, T. en_US
dc.contributor.author Williams, B. en_US
dc.contributor.author Lauer, J. en_US
dc.contributor.author Molenberghs, G. en_US
dc.contributor.author Burzykowski, T. en_US
dc.contributor.author Mulumba, M. en_US
dc.contributor.author Berkvens, D. en_US
dc.date.accessioned 2008-05-21T11:49:23Z
dc.date.available 2008-05-21T11:49:23Z
dc.date.issued 2008
dc.identifier.issn 0014-4894
dc.identifier.doi http://dx.doi.org/10.1016/j.exppara.2007.11.005
dc.identifier.other ITG-A1A en_US
dc.identifier.other ITG-A2A en_US
dc.identifier.other ITG-ALA en_US
dc.identifier.other ANIMAL en_US
dc.identifier.other U-ANIMAL en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other UPD3 en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/2260
dc.description.abstract Theileria parva is the causative agent of East Coast fever (ECF), an important cattle disease in East and Central Africa. One of the methods for control of ECF is 'infection and treatment', a procedure in which an animal is infected with the live parasite and at the same time treated with a long-acting oxytetracycline formulation, restraining the infection and allowing a protective cellular immune response to develop. Optimal immunizing doses were estimated using models of trichotomous response: dysimmunization (death or severe reaction during immunization), immunization failure (death or severe reaction during lethal challenge) and successful immunization (neither dysimmunization nor immunization failure). In this paper we present methods of interpreting immunization trials and apply these methods to previously unpublished data from two such trials: one with a mixture of three T. parva stocks and one with a single T. parva stock. We explain why titration trials conducted with a cocktail of antigens could predict a suboptimal immunization dose. Indeed it is possible for a combination of three individually efficient stocks to result in a mixture with which optimal immunization response might be difficult to achieve, because of averaging effects. The corresponding interpretation provides insights into why standard immunization trials for T. parva have not yielded the results that might be expected of them. The results of this work may also have implications for the use of antigen cocktails in cancer, HIV and malaria vaccine trials.
dc.language English en_US
dc.subject Animal diseases en_US
dc.subject Protozoal diseases en_US
dc.subject East Coast fever en_US
dc.subject Theileria parva en_US
dc.subject Vaccination en_US
dc.subject Dosage en_US
dc.subject Estimation en_US
dc.subject Immunoassay en_US
dc.subject Titration en_US
dc.subject Modeling en_US
dc.subject Statistical methods en_US
dc.subject Clinical trials en_US
dc.subject Evaluation en_US
dc.title Titrating Theileria parva: single stocks against combination of stocks en_US
dc.type Article en_US
dc.citation.issue 4 en_US
dc.citation.jtitle Experimental Parasitology en_US
dc.citation.volume 118 en_US
dc.citation.pages 522-530 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/18155195
dc.citation.jabbreviation Exp Parasitol en_US


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