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High failure rates of melarsoprol for sleeping sickness, Democratic Republic of Congo

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High failure rates of melarsoprol for sleeping sickness, Democratic Republic of Congo

Robays, J.; Nyamowala, G.; Sese, C.; Kande Betu Ku Mesu, V.; Lutumba, P.; Van der Veken, W.; Boelaert, M.
Journal Name:
Emerging Infectious Diseases
Issue Date:
2008
Volume:
14
Issue:
6
Pages:
966-967
Publisher:
National Center for Infectious Diseases
Place:
Atlanta
Pubmed ID:
http://www.ncbi.nlm.nih.gov/pubmed/18507916
Language:
English
Type:
Article
Keywords:
Protozoal diseases
Trypanosomiasis, African
Drug therapy
Melarsoprol
Treatment outcomes
Relapses
Drug resistance
Congo-Kinshasa
Africa, Central

Abstract:

A retrospective chart review of 4,925 human African trypanosomiasis patients treated with melarsoprol in 2001-2003 in Equateur Nord Province of the Democratic Republic of Congo showed a treatment failure rate of 19.5%. This rate increased over the 3 years. Relapse rates were highest in the central part of the province.

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