Institute of Tropical Medicine Antwerp
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Immunopathogenesis of immune reconstitution disease in HIV patients responding to antiretroviral therapy

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Show simple item record Kestens, L. en_US Seddiki, N. en_US Bohjanen, P. R. en_US 2008-07-25T08:45:28Z 2008-07-25T08:45:28Z 2008
dc.identifier.issn 1746-630X
dc.identifier.other ITG-M1A en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-IMMUN en_US
dc.identifier.other UPD5 en_US
dc.identifier.other ABSTRACT en_US
dc.description.abstract Purpose of review: The aim of this article is to review the most recent literature regarding the immunopathogenesis of pathogen-associated immune reconstitution disease and to discuss the role of immune activation and various effector molecules and cells such as macrophages, effector and regulatory T cells, and natural killer cells in immune reconstitution disease. Recent findings: Many HIV patients receiving antiretroviral treatment develop immune reconstitution disease, which is characterized by exaggerated inflammatory immune responses to replicating or dead pathogens. In the majority of these cases, immune reconstitution disease is associated with restoration of pathogen-specific cellular immune responses involving CD4+ or CD8+ effector T cells. The precise conditions that trigger immune reconstitution disease have not yet been identified. Immune reconstitution disease patients have overt immune activation, which may be due to poor homeostatic control after the fast initial immune recovery in patients receiving antiretroviral therapy. Poor homeostatic control in immune reconstitution disease patients may be linked to unbalanced restoration of effector and regulatory T cells. Summary: Although the precise mechanism of immune reconstitution disease is not well understood, it is probably related to rapid restoration of pathogen-specific immune responses and poor homeostatic control that promote exaggerated immunopathological responses, especially if viable pathogens or pathogen debris are present at high concentrations. en_US
dc.language English en_US
dc.subject Viral diseases en_US
dc.subject HIV en_US
dc.subject AIDS en_US
dc.subject Antiretrovirals en_US
dc.subject Drug therapy en_US
dc.subject Adverse effects en_US
dc.subject Inflammatory reactions en_US
dc.subject Immune reconstitution en_US
dc.subject Immunopathogenesis en_US
dc.subject Immune activation en_US
dc.subject Macrophages en_US
dc.subject T-cells en_US
dc.subject Natural killer cells en_US
dc.title Immunopathogenesis of immune reconstitution disease in HIV patients responding to antiretroviral therapy en_US
dc.type Article en_US
dc.citation.issue 4 en_US
dc.citation.jtitle Current Opinion in HIV and AIDS en_US
dc.citation.volume 3 en_US
dc.citation.pages 419-424 en_US
dc.citation.jabbreviation Curr Opin HIV AIDS en_US

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