Institute of Tropical Medicine Antwerp
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Biomedical interventions to prevent HIV infection: evidence, challenges, and way forward

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dc.contributor.author Padian, N. S. en_US
dc.contributor.author Buvé, A. en_US
dc.contributor.author Balkus, J. en_US
dc.contributor.author Serwadda, D. en_US
dc.contributor.author Cates, W. en_US
dc.date.accessioned 2008-09-18T12:27:30Z
dc.date.available 2008-09-18T12:27:30Z
dc.date.issued 2008
dc.identifier.issn 0140-6736
dc.identifier.doi http://dx.doi.org/10.1016/S0140-6736(08)60885-5
dc.identifier.other ITG-M2A en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-MYCOB en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other UPD6 en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/2375
dc.description.abstract Intensive research efforts for more than two decades have not yet resulted in an HIV vaccine of even moderate effectiveness. However, some progress has been made with other biomedical interventions, albeit on the basis of inconsistent levels of evidence. The male condom, if used correctly and consistently, has been proven in observational studies to be very effective in blocking HIV transmission during sexual intercourse; and, in three randomised trials, male circumcision was protective against HIV acquisition among men. Treatment of sexually transmitted infections, a public health intervention in its own right, has had mixed results, depending in part on the epidemic context in which the approach was assessed. Finally, oral and topical antiretroviral compounds are being assessed for their role in reduction of HIV transmission during sexual intercourse. Research on biomedical interventions poses formidable challenges. Difficulties with product adherence and the possibility of sexual disinhibition are important concerns. Biomedical interventions will need to be part of an integrative package that includes biomedical, behavioural, and structural interventions. Assessment of such multicomponent approaches with moderate effects is difficult. Issues to be considered include the nature of control groups and the effect of adherence on the true effectiveness of the intervention. en_US
dc.language English en_US
dc.publisher Elsevier
dc.subject Viral diseases en_US
dc.subject HIV en_US
dc.subject AIDS en_US
dc.subject Prevention strategies en_US
dc.subject Effectiveness en_US
dc.subject Condoms en_US
dc.subject Male circumcision en_US
dc.subject Sexually transmitted diseases en_US
dc.subject STD en_US
dc.subject Case management en_US
dc.subject Drug development en_US
dc.subject Antiretrovirals en_US
dc.subject Vaccine development en_US
dc.subject Compliance en_US
dc.subject Sexual behavior en_US
dc.subject Review of the literature en_US
dc.title Biomedical interventions to prevent HIV infection: evidence, challenges, and way forward en_US
dc.type Article en_US
dc.citation.issue 9638 en_US
dc.citation.jtitle Lancet en_US
dc.citation.volume 372 en_US
dc.citation.pages 585-599 en_US
dc.publisher.place Amsterdam
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/18687456
dc.identifier.url http://www.thelancet.com
dc.citation.jabbreviation Lancet en_US


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