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Differences in immunoregulatory cytokine expression patterns in the systemic and genital tract compartments of HIV-1-infected commercial sex workers in Benin

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dc.contributor.author Lajoie, J.
dc.contributor.author Poudrier, J.
dc.contributor.author Massinga-Loembe, M.
dc.contributor.author Guédou, F.
dc.contributor.author Agossa-Gbenafa, C.
dc.contributor.author Labbé, A. C.
dc.contributor.author Alary, M.
dc.contributor.author Roger, M.
dc.date.accessioned 2009-01-08T15:30:11Z
dc.date.available 2009-01-08T15:30:11Z
dc.date.issued 2008
dc.identifier.issn 1933-0219
dc.identifier.doi http://dx.doi.org/10.1038/mi.2008.18
dc.identifier.other ITG-M3B
dc.identifier.other MICRO
dc.identifier.other U-IMMUN
dc.identifier.other DOI
dc.identifier.other UPD8
dc.identifier.other ABSTRACT
dc.identifier.uri http://hdl.handle.net/10390/2464
dc.description.abstract Initial exposure to human immunodeficiency virus type 1 (HIV-1) during heterosexual transmission occurs in the genital tract. Although much of the literature on the immune response to HIV-1 infection is based on studies performed at the systemic level, our understanding of tissue-specific immunity is lacking. Levels of both genital mucosal and blood interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma production were compared between 57 HIV-1-uninfected and 52 HIV-1-infected female commercial sex workers (CSWs) as well as 73 HIV-1-uninfected non-CSW control women at low risk for exposure. HIV-1-infected CSWs had significantly higher genital mucosal levels of TNF-alpha and IFN-gamma compared with those in both the HIV-uninfected CSW and non-CSW groups. In contrast, the serum levels of all the cytokines tested were lower in HIV-1-infected CSWs compared with those in the other groups. The increased production of genital mucosal pro-inflammatory cytokines in HIV-1-infected CSWs possibly reflects susceptibility to HIV-1 infection and disease progression/perpetuation at the initial site of exposure. en
dc.language English en
dc.subject Viral diseases en
dc.subject HIV-1 en
dc.subject Prostitutes en
dc.subject Cytokine production en
dc.subject Disease progression en
dc.subject Disease susceptibility en
dc.subject Benin en
dc.subject Africa, West en
dc.title Differences in immunoregulatory cytokine expression patterns in the systemic and genital tract compartments of HIV-1-infected commercial sex workers in Benin en
dc.type Article en
dc.citation.issue 4 en
dc.citation.jtitle Mucosal Immunology en
dc.citation.volume 1 en
dc.citation.pages 309-316 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/19079192
dc.citation.jabbreviation Mucosal Immunology en


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