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Determinants of nonadherence to a single-dose nevirapine regimen for the prevention of mother-to-child HIV transmission in Rwanda

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dc.contributor.author Delvaux, T.
dc.contributor.author Elul, B.
dc.contributor.author Ndagije, F.
dc.contributor.author Munyana, E.
dc.contributor.author Roberfroid, D.
dc.contributor.author Asiimwe, A.
dc.date.accessioned 2009-02-13T10:23:36Z
dc.date.available 2009-02-13T10:23:36Z
dc.date.issued 2009
dc.identifier.issn 1525-4135
dc.identifier.doi http://dx.doi.org/10.1097/QAI.0b013e31819001a3
dc.identifier.other ITG-M1A
dc.identifier.other ITG-H5A
dc.identifier.other MULTI
dc.identifier.other MICRO
dc.identifier.other U-HIVSTD
dc.identifier.other HEALTH
dc.identifier.other U-VOED
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other UPD9
dc.identifier.other ABSTRACT
dc.identifier.uri http://hdl.handle.net/10390/2508
dc.description Not the final published version en_US
dc.description.abstract Objectives: To describe experiences, and identify factors associated with nonadherence to a single-dose nevirapine (SD-NVP) regimen for the prevention of mother-to-child transmission (PMTCT) of HIV in Rwanda. Methods: In April to May 2006, using a case-control design at 12 PMTCT sites, we interviewed HIV-infected women who did not adhere (n = 111) and who adhered (n = 125) to the PMTCT prophylaxis regimen. Nonadherence was defined as mother and/or infant not ingesting SD-NVP at the recommended time or not at all and adherence as mother-infant pairs who ingested it as recommended. Results: Only 61% of nonadherent women had received SD-NVP during pregnancy or delivery. Among nonadherent women who received SD-NVP, 80% ingested it at the recommended time, representing 49% of all nonadherent women. Only 7% of their newborns ingested SD-NVP. Multivariate logistic regression showed that unmarried women, less educated women, women who made 2 or less antenatal care visits, and those offered HIV testing after their first antenatal care visit were more likely to be nonadherent to PMTCT prophylaxis. Not disclosing one's HIV status to someone aside from a partner was also associated with nonadherence in mother-infant pairs. Conclusions: Sociodemographic factors, health services delivery factors, and a lack of communication and social support contributed to nonadherence to PMTCT prophylaxis in Rwanda. en
dc.language English en
dc.publisher Lippincott, Williams & Wilkins en_US
dc.subject Viral diseases en
dc.subject HIV en
dc.subject AIDS en
dc.subject Disease transmission, vertical en
dc.subject Mother-to-child en
dc.subject Transmission prevention en
dc.subject Nevirapine en
dc.subject Single dose en
dc.subject Compliance en
dc.subject Determinants en
dc.subject Rwanda en
dc.subject Africa, Central en
dc.title Determinants of nonadherence to a single-dose nevirapine regimen for the prevention of mother-to-child HIV transmission in Rwanda en
dc.type Article en
dc.citation.issue 2 en
dc.citation.jtitle Journal of Acquired Immune Deficiency Syndromes en
dc.citation.volume 50 en
dc.citation.pages 223-230 en
dc.publisher.place Philadelphia en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/19131884
dc.citation.jabbreviation J Acquir Immun Defic Syndr en


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