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Structure, dynamics and function of Leishmania genome: resolving the puzzle of infection, genetics and evolution? [discussion]

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dc.contributor.author Dujardin, J. C. en
dc.date.accessioned 2009-02-20T10:58:49Z
dc.date.available 2009-02-20T10:58:49Z
dc.date.issued 2009
dc.identifier.issn 1567-1348
dc.identifier.doi http://dx.doi.org/10.1016/j.meegid.2008.11.007
dc.identifier.other ITG-PUA en
dc.identifier.other PARAS en
dc.identifier.other U-PROTO en
dc.identifier.other JIF en
dc.identifier.other DOI en
dc.identifier.other ABSTRACT en
dc.identifier.other UPD10 en
dc.identifier.uri http://hdl.handle.net/10390/2526
dc.description.abstract We review and discuss here the specificity and contribution of genome (re-)arrangement studies for the exploration of genetic diversity among Leishmania. We show how the early molecular karyotyping studies generated an original perception of the genetics and evolution of these Protozoa, while providing some possible explanations on the parasite diverse phenotypes (drug resistance, pathogenicity...). We compare the results with the enormous amount of data provided by the recent genome sequencing projects, so far focused on one strain per genus/species. We highlight the relevance of parallel sequencing of different strains of a same species, now made possible by the new sequencing technologies. We recommend paying a particular attention to variation in gene copy number, a feature showed by the karyotyping studies to be extremely informative. en
dc.language English en
dc.subject Protozoology en
dc.subject Leishmania en
dc.subject Molecular epidemiology en
dc.subject Evolutionary genetics en
dc.subject Genetic diversity en
dc.subject Phenotypes en
dc.subject Karyotyping en
dc.subject Genome sequencing en
dc.subject Pathogenicity en
dc.subject Review of the literature en
dc.title Structure, dynamics and function of Leishmania genome: resolving the puzzle of infection, genetics and evolution? [discussion] en
dc.type Article en
dc.citation.issue 2 en
dc.citation.jtitle Infection, Genetics and Evolution en
dc.citation.volume 9 en
dc.citation.pages 290-297 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/19100863
dc.citation.jabbreviation Infect Genet Evol en


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