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First molecular epidemiological study of tuberculosis in Benin

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dc.contributor.author Affolabi, D.
dc.contributor.author Anyo, G.
dc.contributor.author Faïhun, F.
dc.contributor.author Sanoussi, N.
dc.contributor.author Shamputa, I. C.
dc.contributor.author Rigouts, L.
dc.contributor.author Kestens, L.
dc.contributor.author Anagonou, S.
dc.contributor.author Portaels, F.
dc.date.accessioned 2009-03-31T12:43:09Z
dc.date.available 2009-03-31T12:43:09Z
dc.date.issued 2009
dc.identifier.issn 1027-3719
dc.identifier.other ITG-M1B
dc.identifier.other ITG-M2B
dc.identifier.other ITG-M5B
dc.identifier.other ITG-M6A
dc.identifier.other ITG-M7A
dc.identifier.other ITG-MLA
dc.identifier.other MICRO
dc.identifier.other U-MYCOB
dc.identifier.other U-IMMUN
dc.identifier.other JIF
dc.identifier.other UPD11
dc.identifier.other ABSTRACT
dc.identifier.uri http://hdl.handle.net/10390/2598
dc.description.abstract OBJECTIVES: To assess the diversity of Mycobacterium tuberculosis strains in Cotonou, Benin, and the risk factors associated with clustering. METHODS: We analysed one sputum sample from 194 consecutive new pulmonary tuberculosis (TB) cases using two genotyping methods: spoligotyping and the 12 loci mycobacterial interspersed repetitive unit-variable number of tandem repeats (MIRU-VNTR). The data obtained were compared to the SpolDB4.0 database. RESULTS: We have found that spoligotype 61, highly predominant in West Africa, was also the most prevalent strain in Cotonou. We observed that the Beijing family represented 10.3% of strains and was associated with resistance to streptomycin. We also confirmed that combining spoligotyping and MIRU-VNTR provided a higher discriminatory power than the two techniques used individually. CONCLUSION: Spoligotype 61 and Beijing genotype are the most prevalent genotypes of M. tuberculosis in Cotonou. en
dc.language English en
dc.publisher International Union Against Tuberculosis And Lung Disease en
dc.subject Bacterial diseases en
dc.subject Tuberculosis en
dc.subject Mycobacterium tuberculosis en
dc.subject Molecular epidemiology en
dc.subject Genetic diversity en
dc.subject Clustering en
dc.subject Genotypes en
dc.subject Spoligotyping en
dc.subject MIRU-VNTR en
dc.subject Benin en
dc.subject Africa, West en
dc.title First molecular epidemiological study of tuberculosis in Benin en
dc.type Article en
dc.citation.issue 3 en
dc.citation.jtitle International Journal of Tuberculosis and Lung Disease en
dc.citation.volume 13 en
dc.citation.pages 317-322 en
dc.publisher.place Paris
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/19275790
dc.citation.jabbreviation Int J Tuberc Lung Dis en


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