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Urine antigen detection for the diagnosis of human neurocysticercosis

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dc.contributor.author Castillo, Y.
dc.contributor.author Rodriguez, S.
dc.contributor.author García, H. H.
dc.contributor.author Brandt, J.
dc.contributor.author Van Hul, A.
dc.contributor.author Silva, M.
dc.contributor.author Rodriguez-Hidalgo, R.
dc.contributor.author Portocarrero, M.
dc.contributor.author Melendez, D. P.
dc.contributor.author Gonzalez, A. E.
dc.contributor.author Gilman, R. H.
dc.contributor.author Dorny, P.
dc.date.accessioned 2009-04-01T14:39:19Z
dc.date.available 2009-04-01T14:39:19Z
dc.date.issued 2009
dc.identifier.issn 0002-9637
dc.identifier.other ITG-X4A
dc.identifier.other ITG-A5B
dc.identifier.other ITG-ALA
dc.identifier.other ANIMAL
dc.identifier.other U-ANIMAL
dc.identifier.other JIF
dc.identifier.other UPD11
dc.identifier.other ABSTRACT
dc.identifier.uri http://hdl.handle.net/10390/2617
dc.description.abstract Neurocysticercosis (NCC) is a major cause of seizures and epilepsy. Diagnosis is based on brain imaging, supported by immunodiagnosis in serum or cerebrospinal fluid (CSF). Lumbar puncture is invasive and painful. Blood sampling is slightly painful and poorly accepted. Urine antigen detection has been used for other parasites and tried in NCC with suboptimal performance. We used a monoclonal antibody-based ELISA to detect Taenia solium antigens in urine from 87 Peruvian neurocysticercosis patients (viable cysts, N = 34; subarachnoid cysticercosis, N = 10; degenerating parasites, N = 7; calcified lesions, N = 36) and 32 volunteers from a non-endemic area of Peru. Overall sensitivity of urine antigen detection for viable parasites was 92%, which decreased to 62.5% in patients with a single cyst. Most patients (30/36, 83%) with only calcified cysticercosis were urine antigen negative. Antigen levels in paired serum/urine samples (evaluated in 19 patients) were strongly correlated. Non-invasive urine testing for T. solium antigens provides a useful alternative for NCC diagnosis. en
dc.language English en
dc.subject Helminthic diseases en
dc.subject Neurocysticercosis en
dc.subject Human en
dc.subject Laboratory diagnosis en
dc.subject Antigen detection en
dc.subject Urine en
dc.subject Taenia solium en
dc.subject Peru en
dc.subject America, Latin en
dc.title Urine antigen detection for the diagnosis of human neurocysticercosis en
dc.type Article en
dc.citation.issue 3 en
dc.citation.jtitle American Journal of Tropical Medicine and Hygiene en
dc.citation.volume 80 en
dc.citation.pages 379-383 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/19270285
dc.citation.jabbreviation Am J Trop Med Hyg en


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