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Presence of a multidrug-resistance mutation in an HIV-2 variant infecting a treatment-naive individual in Caio, Guinea Bissau

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Presence of a multidrug-resistance mutation in an HIV-2 variant infecting a treatment-naive individual in Caio, Guinea Bissau

Jallow, S.; Vincent, T.; Leligdowicz, A.; De Silva, T.; Van Tienen, C.; Alabi, A.; Sarge-Njie, R.; Aaby, P.; Corrah, T.; Whittle, H.; Jaye, A.; Vanham, G.; Rowland-Jones, S.; Janssens, W.
Journal Name:
Clinical Infectious Diseases
Issue Date:
2009
Volume:
48
Issue:
12
Pages:
1790-1793
Publisher:
University of Chicago Press
DOI:
http://dx.doi.org/10.1086/599107
Pubmed ID:
http://www.ncbi.nlm.nih.gov/pubmed/19438401
Language:
English
Type:
Article
Keywords:
Viral diseases
HIV-2
AIDS
Multidrug resistance
Mutations
Viral fitness
Phylogenetics
Surveys
Guinea-Bissau
Africa, West

Abstract:

We report the possible transmission of drug-resistant human immunodeficiency virus type 2. A 66-year-old woman from rural Guinea Bissau who had no obvious antiretroviral exposure was found to harbor a variant with the multidrug-resistance mutation Q151M. Finding this mutation among a drug-naive population presents an important public health issue that needs to be addressed for treatment to be effective.

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