Institute of Tropical Medicine Antwerp
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Weighing harm in therapeutic decisions of smear-negative pulmonary tuberculosis

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dc.contributor.author Moreira, J.
dc.contributor.author Bisig, B.
dc.contributor.author Muwawenimana, P.
dc.contributor.author Basinga, P.
dc.contributor.author Bisoffi, Z.
dc.contributor.author Haegeman, F.
dc.contributor.author Kishore, P.
dc.contributor.author Van den Ende, J.
dc.date.accessioned 2009-07-08T08:36:06Z
dc.date.available 2009-07-08T08:36:06Z
dc.date.issued 2009
dc.identifier.issn 0272-989X
dc.identifier.doi http://dx.doi.org/10.1177/0272989X08327330
dc.identifier.other ITG-C1B
dc.identifier.other ITG-C2B
dc.identifier.other ITG-CLA
dc.identifier.other CLINIC
dc.identifier.other U-TROPIC
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other UPD15
dc.identifier.other ABSTRACT
dc.identifier.uri http://hdl.handle.net/10390/2723
dc.description.abstract PURPOSE: To relate the intuitive weight of harm by commission and harm by omission in therapeutic decisions for pulmonary tuberculosis, and to compare it with a weight based on probabilities. METHODS: Clinicians were asked for an estimation of probabilities related with the outcome of treated and nontreated pulmonary tuberculosis and for the toll of wrong decisions. Three ratios of the weight of forgoing a treatment in false-negative patients against the weight of treating false-positives were calculated. The first was based on intuitive estimations, whereas the second and third were based on calculated, either through intuitive estimations of probabilities or through literature data. The association between experience and the difference between the intuitive and the calculated ratios was assessed. RESULTS: Eighty-one participants from Ecuador, Laos, Nepal, and Rwanda responded. The ratio of intuitive weights was 2.0 (interquartile range [IQR], 1.0-4.0) and the ratio of calculated weights based on intuitive probabilities was 64 (IQR, 25.0-169.6; P < 0.001). The ratio of calculated weight based on literature probabilities was 30 (IQR, 17.9-59.2). No association (R(2) = 0.03) was found between experience and accuracy in estimating the weight of errors. CONCLUSION: The weight of a false negative is more important than the weight of a false positive for therapeutic decisions in pulmonary tuberculosis. The ratio of the intuitively estimated weights was much lower than the calculation based on intuitively estimated influencing factors. Clinicians were accurate in estimating probabilities but failed to incorporate them into therapeutic decisions. en
dc.language English en
dc.subject Bacterial diseases en
dc.subject Tuberculosis en
dc.subject False-negative en
dc.subject False-positive en
dc.subject Medical care en
dc.subject Decision making en
dc.subject Omission bias en
dc.subject Weight of harm en
dc.subject Probabilities en
dc.subject Threshold en
dc.subject Developing countries en
dc.title Weighing harm in therapeutic decisions of smear-negative pulmonary tuberculosis en
dc.type Article en
dc.citation.issue 3 en
dc.citation.jtitle Medical Decision Making en
dc.citation.volume 29 en
dc.citation.pages 380-390 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/19224870
dc.citation.jabbreviation Med Decision Making en


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