Institute of Tropical Medicine Antwerp
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Antibiotic resistance among bacterial pathogens in Central Africa: a review of the published literature between 1955 and 2008

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dc.contributor.author Vlieghe, E.
dc.contributor.author Phoba, M. F.
dc.contributor.author Muyembe Tamfum, J. J.
dc.contributor.author Jacobs, J.
dc.date.accessioned 2009-09-07T12:13:20Z
dc.date.available 2009-09-07T12:13:20Z
dc.date.issued 2009
dc.identifier.issn 0924-8579
dc.identifier.doi http://dx.doi.org/10.1016/j.ijantimicag.2009.04.015
dc.identifier.other ITG-C1A
dc.identifier.other ITG-CLA
dc.identifier.other CLINIC
dc.identifier.other U-HIVCLI
dc.identifier.other U-CLIBIO
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other UPD16
dc.identifier.other ABSTRACT
dc.identifier.uri http://hdl.handle.net/10390/2788
dc.description.abstract A systematic review of the published literature on bacterial resistance in Central Africa between 1955 and 2008 was performed. Eighty-three publications from seven countries were retrieved, the majority presenting data on enteric and other gram-negative pathogens. Despite methodological limitations in many studies, alarming resistance rates are noted in nearly all pathogens. Of special concern are multidrug resistance in Shigella and Salmonella spp. and the emergence of meticillin-resistant Staphylococcus aureus, high-level penicillin-resistant Streptococcus pneumoniae and extended-spectrum beta-lactamases among gram-negative pathogens. These findings make clear that the Central African region shares the worldwide trend of increasing antimicrobial resistance and is in urgent need of sound surveillance based on competent and affordable microbiology to provide clear data on antimicrobial resistance. These data could enable redaction of local treatment guidelines and fuel national and regional policies to contain antimicrobial resistance. en
dc.language English en
dc.subject Antimicrobial agents en
dc.subject Antibiotics en
dc.subject Drug resistance en
dc.subject Multidrug resistance en
dc.subject Prevalence en
dc.subject Trends en
dc.subject Systematic review en
dc.subject Africa, Central en
dc.title Antibiotic resistance among bacterial pathogens in Central Africa: a review of the published literature between 1955 and 2008 en
dc.type Article en
dc.citation.issue 4 en
dc.citation.jtitle International Journal of Antimicrobial Agents en
dc.citation.volume 34 en
dc.citation.pages 295-303 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/19540725
dc.citation.jabbreviation Int J Antimicrob Agents en


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