dc.contributor.author | Katwere, M. | |
dc.contributor.author | Kambugu, A. | |
dc.contributor.author | Piloya, T. | |
dc.contributor.author | Wong, M. | |
dc.contributor.author | Hendel-Paterson, B. | |
dc.contributor.author | Sande, M. A. | |
dc.contributor.author | Ronald, A. | |
dc.contributor.author | Katabira, E. | |
dc.contributor.author | Were, E. M. | |
dc.contributor.author | Menten, J. | |
dc.contributor.author | Colebunders, R. | |
dc.date.accessioned | 2009-12-16T09:39:02Z | |
dc.date.available | 2009-12-16T09:39:02Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 1758-2652 | |
dc.identifier.doi | http://dx.doi.org/10.1186/1758-2652-12-21 | |
dc.identifier.other | ITG-I10A | |
dc.identifier.other | ITG-CLA | |
dc.identifier.other | INTER | |
dc.identifier.other | U-CTU | |
dc.identifier.other | CLINIC | |
dc.identifier.other | U-HIVCLI | |
dc.identifier.other | ELECTRONIC | |
dc.identifier.other | DOI | |
dc.identifier.other | URL | |
dc.identifier.other | UPD17 | |
dc.identifier.other | FTA | |
dc.identifier.other | ABSTRACT | |
dc.identifier.uri | http://hdl.handle.net/10390/2799 | |
dc.description.abstract | ABSTRACT: BACKGROUND: We set out to define the relative prevalence and common presentations of the various aetiologies of headache within an ambulant HIV-seropositive adult population in Kampala, Uganda. METHODS: We conducted a prospective study of adult HIV-1-seropositive ambulatory patients consecutively presenting with new onset headaches. Patients were classified as focal-febrile, focal-afebrile, non-focal-febrile or non-focal-afebrile, depending on presence or absence of fever and localizing neurological signs. Further management followed along a pre-defined diagnostic algorithm to an endpoint of a diagnosis. We assessed outcomes during four months of follow up. RESULTS: One hundred and eighty patients were enrolled (72% women). Most subjects presented at WHO clinical stages III and IV of HIV disease, with a median Karnofsky performance rating of 70% (IQR 60-80).The most common diagnoses were cryptococcal meningitis (28%, n = 50) and bacterial sinusitis (31%, n = 56). Less frequent diagnoses included cerebral toxoplasmosis (4%, n = 7), and tuberculous meningitis (4%, n = 7). Thirty-two (18%) had other diagnoses (malaria, bacteraemia, etc.). No aetiology could be elucidated in 28 persons (15%). Overall mortality was 13.3% (24 of 180) after four months of follow up. Those without an established headache aetiology had good clinical outcomes, with only one death (4% mortality), and 86% were ambulatory at four months. CONCLUSION: In an African HIV-infected ambulatory population presenting with new onset headache, aetiology was found in at least 70%. Cryptococcal meningitis and sinusitis accounted for more than half of the cases. | en |
dc.language | English | en |
dc.subject | Viral diseases | en |
dc.subject | HIV | en |
dc.subject | AIDS | en |
dc.subject | Opportunistic infections | en |
dc.subject | Clinical manifestations | en |
dc.subject | Headache | en |
dc.subject | Etiology | en |
dc.subject | Diagnosis | en |
dc.subject | Uganda | en |
dc.subject | Africa, East | en |
dc.title | Clinical presentation and aetiologies of acute or complicated headache among HIV-seropositive patients in a Ugandan clinic | en |
dc.type | Article-E | en |
dc.citation.issue | 21 | en |
dc.citation.jtitle | Journal of the International AIDS Society | en |
dc.citation.volume | 12 | en |
dc.citation.pages | 8 pp. | en |
dc.identifier.pmid | http://www.ncbi.nlm.nih.gov/pubmed/19765315 | |
dc.identifier.url | http://www.jiasociety.org/content/12/1/21 | |
dc.citation.jabbreviation | J Int AIDS Soc | en |