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Bidirectional introgressive hybridization between a cattle and human schistosome species

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dc.contributor.author Huyse, T.
dc.contributor.author Webster, B. L.
dc.contributor.author Geldof, S.
dc.contributor.author Stothard, J. R.
dc.contributor.author Diaw, O. T.
dc.contributor.author Polman, K.
dc.contributor.author Rollinson, D.
dc.date.accessioned 2009-12-16T15:06:44Z
dc.date.available 2009-12-16T15:06:44Z
dc.date.issued 2009
dc.identifier.issn 1553-7366
dc.identifier.issn ABSTRACT
dc.identifier.doi http://dx.doi.dx/10.1371/journal.ppat.1000571
dc.identifier.other ITG-P1B
dc.identifier.other ITG-P6A
dc.identifier.other PARAS
dc.identifier.other U-SCHISTO
dc.identifier.other JIF
dc.identifier.other ELECTRONIC
dc.identifier.other DOI
dc.identifier.other UPD17
dc.identifier.other FTA
dc.identifier.uri http://hdl.handle.net/10390/2816
dc.description.abstract Schistosomiasis is a disease of great medical and veterinary importance in tropical and subtropical regions, caused by parasitic flatworms of the genus Schistosoma (subclass Digenea). Following major water development schemes in the 1980s, schistosomiasis has become an important parasitic disease of children living in the Senegal River Basin (SRB). During molecular parasitological surveys, nuclear and mitochondrial markers revealed unexpected natural interactions between a bovine and human Schistosoma species: S. bovis and S. haematobium, respectively. Hybrid schistosomes recovered from the urine and faeces of children and the intermediate snail hosts of both parental species, Bulinus truncatus and B. globosus, presented a nuclear ITS rRNA sequence identical to S. haematobium, while the partial mitochondrial cox1 sequence was identified as S. bovis. Molecular data suggest that the hybrids are not 1st generation and are a result of parental and/or hybrid backcrosses, indicating a stable hybrid zone. Larval stages with the reverse genetic profile were also found and are suggested to be F1 progeny. The data provide indisputable evidence for the occurrence of bidirectional introgressive hybridization between a bovine and a human Schistosoma species. Hybrid species have been found infecting B. truncatus, a snail species that is now very abundant throughout the SRB. The recent increase in urinary schistosomiasis in the villages along the SRB could therefore be a direct effect of the increased transmission through B. truncatus. Hybridization between schistosomes under laboratory conditions has been shown to result in heterosis (higher fecundity, faster maturation time, wider intermediate host spectrum), having important implications on disease prevalence, pathology and treatment. If this new hybrid exhibits the same hybrid vigour, it could develop into an emerging pathogen, necessitating further control strategies in zones where both parental species overlap. en
dc.language English en
dc.subject Helminthology en
dc.subject Schistosoma en
dc.subject Hybridization en
dc.subject Introgression en
dc.subject Senegal en
dc.subject Africa, West en
dc.title Bidirectional introgressive hybridization between a cattle and human schistosome species en
dc.type Article-E en
dc.citation.issue 9 en
dc.citation.jtitle PLoS Pathogens en
dc.citation.volume 5 en
dc.citation.pages 9 pp. en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/19730700
dc.citation.jabbreviation PLoS Pathog en


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