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HIV type 1 subtype A envelope genetic evolution in a slow progressing individual with consistent broadly neutralizing antibodies

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dc.contributor.author Dieltjens, T.
dc.contributor.author Loots, N.
dc.contributor.author Vereecken, K.
dc.contributor.author Grupping, K.
dc.contributor.author Heyndrickx, L.
dc.contributor.author Bottieau, E.
dc.contributor.author Vanham, G.
dc.contributor.author Davis, D.
dc.contributor.author Janssens, W.
dc.date.accessioned 2009-12-17T14:54:17Z
dc.date.available 2009-12-17T14:54:17Z
dc.date.issued 2009
dc.identifier.issn 0889-2229
dc.identifier.other ITG-M1B
dc.identifier.other ITG-M2B
dc.identifier.other ITG-M3B
dc.identifier.other ITG-M4B
dc.identifier.other ITG-M5A
dc.identifier.other ITG-C6A
dc.identifier.other ITG-M7A
dc.identifier.other ITG-MLA
dc.identifier.other MULTI
dc.identifier.other MICRO
dc.identifier.other U-VIROL
dc.identifier.other CLINIC
dc.identifier.other U-HIVSTD
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other UPD17
dc.identifier.other ABSTRACT
dc.identifier.other FTA
dc.identifier.uri http://hdl.handle.net/10390/2836
dc.description.abstract Studies of viruses taken from individuals with broad cross-neutralizing antibodies against primary isolates may reveal novel antibody specificities and their associated epitopes that could be useful for immunogen design. We report on the Env antigenic variability of a slow progressing HIV-1 subtype A-infected donor with consistent broad cross-neutralizing antibodies during the second decade of disease progression after vertical transmission. The Env evolution is characterized by a genetic shift to variants with altered V1-V5 loop sequences, marked by consecutive changes in V1, V4-V5, and C3 and largely conserved V2 and V3 loop sequences. Major V1 Env sequence expansion, variation by a duplication event, and cumulative addition of cysteine residues and potential N-glycosylation sites over time may contribute to escape from antibody pressure directed to Env receptor domains by changing the exposure of neutralization-sensitive epitopes. Conservation of functional epitopes may correlate with the continued presence of broad cross-neutralizing antibodies. en
dc.language English en
dc.subject Viral diseases en
dc.subject HIV-1 en
dc.title HIV type 1 subtype A envelope genetic evolution in a slow progressing individual with consistent broadly neutralizing antibodies en
dc.type Article en
dc.citation.issue 11 en
dc.citation.jtitle AIDS Research and Human Retroviruses en
dc.citation.volume 25 en
dc.citation.pages 1165-1169 en
dc.identifier.pmid http://dx.doi.org/10.1089/aid.2008.0161
dc.citation.jabbreviation AIDS Res Hum Retroviruses en


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