Institute of Tropical Medicine Antwerp
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HIV type 1 subtype A envelope genetic evolution in a slow progressing individual with consistent broadly neutralizing antibodies

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Show simple item record Dieltjens, T. Loots, N. Vereecken, K. Grupping, K. Heyndrickx, L. Bottieau, E. Vanham, G. Davis, D. Janssens, W. 2009-12-17T14:54:17Z 2009-12-17T14:54:17Z 2009
dc.identifier.issn 0889-2229
dc.identifier.other ITG-M1B
dc.identifier.other ITG-M2B
dc.identifier.other ITG-M3B
dc.identifier.other ITG-M4B
dc.identifier.other ITG-M5A
dc.identifier.other ITG-C6A
dc.identifier.other ITG-M7A
dc.identifier.other ITG-MLA
dc.identifier.other MULTI
dc.identifier.other MICRO
dc.identifier.other U-VIROL
dc.identifier.other CLINIC
dc.identifier.other U-HIVSTD
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other UPD17
dc.identifier.other ABSTRACT
dc.identifier.other FTA
dc.description.abstract Studies of viruses taken from individuals with broad cross-neutralizing antibodies against primary isolates may reveal novel antibody specificities and their associated epitopes that could be useful for immunogen design. We report on the Env antigenic variability of a slow progressing HIV-1 subtype A-infected donor with consistent broad cross-neutralizing antibodies during the second decade of disease progression after vertical transmission. The Env evolution is characterized by a genetic shift to variants with altered V1-V5 loop sequences, marked by consecutive changes in V1, V4-V5, and C3 and largely conserved V2 and V3 loop sequences. Major V1 Env sequence expansion, variation by a duplication event, and cumulative addition of cysteine residues and potential N-glycosylation sites over time may contribute to escape from antibody pressure directed to Env receptor domains by changing the exposure of neutralization-sensitive epitopes. Conservation of functional epitopes may correlate with the continued presence of broad cross-neutralizing antibodies. en
dc.language English en
dc.subject Viral diseases en
dc.subject HIV-1 en
dc.title HIV type 1 subtype A envelope genetic evolution in a slow progressing individual with consistent broadly neutralizing antibodies en
dc.type Article en
dc.citation.issue 11 en
dc.citation.jtitle AIDS Research and Human Retroviruses en
dc.citation.volume 25 en
dc.citation.pages 1165-1169 en
dc.citation.jabbreviation AIDS Res Hum Retroviruses en

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