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Prenatal food supplementation fortified with multiple micronutrients increases birth length: a randomized controlled trial in rural Burkina Faso

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Show simple item record Huybregts, L. Roberfroid, D. Lanou, H. Menten, J. Meda, N. Van Camp, J. Kolsteren, P. 2009-12-17T15:12:20Z 2009-12-17T15:12:20Z 2009
dc.identifier.issn 0002-9165
dc.identifier.other ITG-H2A
dc.identifier.other ITG-I4A
dc.identifier.other ITG-HLA
dc.identifier.other HEALTH
dc.identifier.other U-VOED
dc.identifier.other INTER
dc.identifier.other U-CTU
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other UPD17
dc.identifier.other ABSTRACT
dc.description.abstract BACKGROUND: Prenatal multiple micronutrient (MMN) or balanced energy and protein supplementation has a limited effect on birth size of the offspring. OBJECTIVE: The objective was to determine whether a prenatal MMN-fortified food supplement (FFS) improves anthropometric measures at birth compared with supplementation with an MMN pill alone. DESIGN: We conducted a nonblinded, individually randomized controlled trial in 1296 pregnant women in 2 villages in rural Burkina Faso. Supplements were provided on a daily basis, and compliance was closely verified by using a community-based network of home visitors. RESULTS: Anthropometric measures at birth were available for analysis for 87% of the 1175 live singleton deliveries enrolled. After adjustment for gestational age at birth, the FFS group had a significantly higher birth length (+4.6 mm; P = 0.001). FFS supplementation resulted in a modestly higher birth weight (+31 g; P = 0.197). Subgroup analyses showed clinically important treatment effects on birth length (+12.0 mm; P = 0.005) and on birth weight (+111 g; P = 0.133) for underweight [body mass index (in kg/m(2)) <18.5] pregnant women. Women with early pregnancy anemia who received FFS gave birth to longer newborns (+7.3 mm; P = 0.002) than did those who received MMN supplementation. CONCLUSIONS: The provision of FFS to pregnant women resulted in higher birth length than did MMN supplementation. For women with a suboptimal prepregnancy nutritional status, MMN supplementation should be complemented with a balanced energy and protein supplement to produce a clinical effect on birth size. The trial was registered at as NCT00909974. en
dc.language English en
dc.subject Pregnancy en
dc.subject Dietary supplements en
dc.subject Food supplementation en
dc.subject Micronutrients en
dc.subject Impact assessment en
dc.subject Body length en
dc.subject Burkina Faso en
dc.subject Africa, West en
dc.title Prenatal food supplementation fortified with multiple micronutrients increases birth length: a randomized controlled trial in rural Burkina Faso en
dc.type Article en
dc.citation.issue 6 en
dc.citation.jtitle American Journal of Clinical Nutrition en
dc.citation.volume 90 en
dc.citation.pages 1593-1600 en
dc.contributor.corpauthor MISAME Study Group en
dc.citation.jabbreviation Am J Clin Nutr en

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