Institute of Tropical Medicine Antwerp
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Nutritional stress affects the tsetse fly's immune gene expression

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Show simple item record Akoda, K. Van den Bossche, P. Marcotty, T. Kubi, C. Coosemans, M. De Deken, R. Van Den Abbeele, J. 2009-12-18T12:01:13Z 2009-12-18T12:01:13Z 2009
dc.identifier.issn 0269-283X
dc.identifier.issn ABSTRACT
dc.identifier.other ITG-A1B
dc.identifier.other ITG-A2A
dc.identifier.other ITG-A3A
dc.identifier.other ITG-A4B
dc.identifier.other ITG-P5A
dc.identifier.other ITG-A6A
dc.identifier.other ITG-PLA
dc.identifier.other MULTI
dc.identifier.other ANIMAL
dc.identifier.other U-ANIMAL
dc.identifier.other PARAS
dc.identifier.other U-ENTOM
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other UPD17
dc.description.abstract Tsetse-transmitted trypanosomiasis poses a serious threat to human and animal health in sub-Saharan Africa. The majority of tsetse flies (Glossina spp.) in a natural population will not develop a mature infection of either Trypanosoma congolense or Trypanosoma brucei sp. because of refractoriness, a phenomenon that is affected by different factors, including the tsetse fly's immune defence. Starvation of tsetse flies significantly increases their susceptibility to the establishment of a trypanosome infection. This paper reports the effects of nutritional stress (starvation) on (a) uninduced baseline levels of gene expression of the antimicrobial peptides attacin, defensin and cecropin in the tsetse fly, and (b) levels of expression induced in response to bacterial (Escherichia coli) or trypanosomal challenge. In newly emerged, unfed tsetse flies, starvation significantly lowers baseline levels of antimicrobial peptide gene expression, especially for attacin and cecropin. In response to trypanosome challenge, only non-starved older flies showed a significant increase in antimicrobial peptide gene expression within 5 days of ingestion of a trypanosome-containing bloodmeal, especially with T. brucei bloodstream forms. These data suggest that a decreased expression of immune genes in newly hatched flies or a lack of immune responsiveness to trypanosomes in older flies, both occurring as a result of fly starvation, may be among the factors contributing to the increased susceptibility of nutritionally stressed tsetse flies to trypanosome infection. en
dc.language English en
dc.subject Entomology en
dc.subject Tsetse flies en
dc.subject Glossina morsitans en
dc.subject Vectorial competence en
dc.subject Protozoal diseases en
dc.subject Trypanosomiasis, African en
dc.subject Trypanosoma brucei brucei en
dc.subject Trypanosoma congolense en
dc.subject Immune response en
dc.subject Peptides en
dc.subject Gene expression en
dc.subject Starvation en
dc.subject Nutritional stress en
dc.subject Disease susceptibility en
dc.title Nutritional stress affects the tsetse fly's immune gene expression en
dc.type Article en
dc.citation.issue 3 en
dc.citation.jtitle Medical and Veterinary Entomology en
dc.citation.volume 23 en
dc.citation.pages 195-201 en
dc.citation.jabbreviation Med Vet Entomol en

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