Institute of Tropical Medicine Antwerp
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History, dynamics, and public health importance of malaria parasite resistance

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dc.contributor.author Talisuna, A. O. en_US
dc.contributor.author Bloland, P. en_US
dc.contributor.author D'Alessandro, U. en_US
dc.date.accessioned 2007-12-06T14:34:11Z
dc.date.available 2007-12-06T14:34:11Z
dc.date.issued 2004 en_US
dc.identifier.issn 0893-8512 en_US
dc.identifier.doi http://dx.doi.org/10.1128/CMR.17.1.235-254.2004
dc.identifier.other ITG-P1B en_US
dc.identifier.other ITG-PLA en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-MALAR en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/284
dc.description.abstract Despite considerable efforts, malaria is still one of the most devastating infectious diseases in the tropics. The rapid spread of antimalarial drug resistance currently compounds this grim picture. In this paper, we review the history of antimalarial drug resistance and the methods for monitoring it and assess the current magnitude and burden of parasite resistance to two commonly used drugs: chloroquine and sulfadoxine-pyrimethamine. Furthermore, we review the factors involved in the emergence and spread of drug resistance and highlight its public health importance. Finally, we discuss ways of dealing with such a problem by using combination therapy and suggest some of the research themes needing urgent answers. en_US
dc.language English en_US
dc.publisher American Society for Microbiology en_US
dc.subject Protozoal diseases en_US
dc.subject Malaria en_US
dc.subject Plasmodium falciparum en_US
dc.subject Plasmodium vivax en_US
dc.subject Antimalarials en_US
dc.subject Chloroquine en_US
dc.subject Sulfadoxine-pyrimethamine en_US
dc.subject Drug resistance en_US
dc.subject Monitoring en_US
dc.subject Molecular markers en_US
dc.subject Impact assessment en_US
dc.subject Epidemics en_US
dc.subject Costs en_US
dc.subject Combination therapy en_US
dc.subject Artemisinin combination therapies (ACT) en_US
dc.title History, dynamics, and public health importance of malaria parasite resistance en_US
dc.type Article en_US
dc.citation.issue 1 en_US
dc.citation.jtitle Clinical Microbiology Reviews en_US
dc.citation.volume 17 en_US
dc.citation.pages 235-254 en_US
dc.publisher.place Washington en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/14726463
dc.citation.jabbreviation Clin Microbiol Rev en_US


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