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Clinical practice: diagnosis of childhood tuberculosis

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dc.contributor.author Rigouts, L.
dc.date.accessioned 2009-12-22T08:11:03Z
dc.date.available 2009-12-22T08:11:03Z
dc.date.issued 2009
dc.identifier.issn 0340-6199
dc.identifier.doi http://dx.doi.org/10.1007/s00431-009-0988-y
dc.identifier.other ITG-MUA
dc.identifier.other MICRO
dc.identifier.other U-MYCOB
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other UPD17
dc.identifier.other ABSTRACT
dc.identifier.uri http://hdl.handle.net/10390/2875
dc.description.abstract Childhood tuberculosis (TB) represents an important part of the disease burden, yet its diagnosis remains challenging. This review summarizes the clinical, radiological, and bacteriological approaches to diagnose TB infection and disease in children. Fever (possibly intermittent or low grade), weight loss or failure to thrive, and a persistent cough for >2 weeks are the most important clinical signs for pulmonary tuberculosis. Extra-pulmonary TB, which might occur in over 40% of the patients, can have in addition some specific clinical symptoms or signs. Chest radiographs provide important information in many patients and advanced imaging can be applied in case of (and should be restricted to) inconclusive diagnosis. The Mantoux test is positive in up to 70% of non-immunocompromised TB patients, whereas HIV co-infection or malnourishment results in a lower reactivity. Evidence of an adult TB index case is clue for diagnosis of childhood TB in low-endemic countries. Bacteriological confirmation remains difficult and is useful for doubtful cases or when drug resistance is suspected. en
dc.language English en
dc.subject Bacterial diseases en
dc.subject Tuberculosis en
dc.subject Children en
dc.subject Clinical diagnosis en
dc.subject Clinical manifestations en
dc.subject Imaging en
dc.subject Mantoux reaction en
dc.subject Immunodeficiency en
dc.subject Malnutrition en
dc.subject Reactivity en
dc.title Clinical practice: diagnosis of childhood tuberculosis en
dc.type Article en
dc.citation.issue 11 en
dc.citation.jtitle European Journal of Pediatrics en
dc.citation.volume 168 en
dc.citation.pages 1285-1290 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/19396462
dc.citation.jabbreviation Eur J Pediatr en


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