Institute of Tropical Medicine Antwerp
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Pathogenetic mechanisms of the intracellular parasite Mycobacterium ulcerans leading to Buruli ulcer

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dc.contributor.author Silva, M. T.
dc.contributor.author Portaels, F.
dc.contributor.author Pedrosa, J.
dc.date.accessioned 2009-12-22T08:44:38Z
dc.date.available 2009-12-22T08:44:38Z
dc.date.issued 2009
dc.identifier.issn 1473-3099
dc.identifier.doi http://dx.doi.org/ 10.1016/S1473-3099(09)70234-8
dc.identifier.other ITG-M2A
dc.identifier.other MICRO
dc.identifier.other U-MYCOB
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other UPD17
dc.identifier.other ABSTRACT
dc.identifier.uri http://hdl.handle.net/10390/2877
dc.description.abstract The necrotising skin infection Buruli ulcer is at present the third most common human mycobacteriosis worldwide, after tuberculosis and leprosy. Buruli ulcer is an emergent disease that is predominantly found in humid tropical regions. There is no vaccine against Buruli ulcer and its treatment is difficult. In addition to the huge social effect, Buruli ulcer is of great scientific interest because of the unique characteristics of its causative organism, Mycobacterium ulcerans. This pathogen is genetically very close to the typical intracellular parasites Mycobacterium marinum and Mycobacterium tuberculosis. We review data supporting the interpretation that M ulcerans has the essential hallmarks of an intracellular parasite, producing infections associated with immunologically relevant inflammatory responses, cell-mediated immunity, and delayed-type hypersensitivity. This interpretation judges that whereas M ulcerans behaves like the other pathogenic mycobacteria, it represents an extreme in the biodiversity of this family of pathogens because of its higher cytotoxicity due to the secretion of the exotoxin mycolactone. The acceptance of the interpretation that Buruli ulcer is caused by an intracellular parasite has relevant prophylactic and therapeutic implications, rather than representing the mere attribution of a label with academic interest, because it prompts the development of vaccines that boost cell-mediated immunity and the use of chemotherapeutic protocols that include intracellularly active antibiotics. en
dc.language English en
dc.subject Bacterial diseases en
dc.subject Mycobacterial diseases en
dc.subject Buruli ulcer en
dc.subject Mycobacterium ulcerans en
dc.subject Pathogenesis en
dc.subject Review of the literature en
dc.title Pathogenetic mechanisms of the intracellular parasite Mycobacterium ulcerans leading to Buruli ulcer en
dc.type Article en
dc.citation.issue 11 en
dc.citation.jtitle Lancet Infectious Diseases en
dc.citation.volume 9 en
dc.citation.pages 699-710 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/19850228
dc.citation.jabbreviation Lancet Infect Dis en


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