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Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes

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dc.contributor.author Van den Bossche, J.
dc.contributor.author Bogaert, P.
dc.contributor.author van Hengel, J.
dc.contributor.author Guerin, C. J.
dc.contributor.author Berx, G.
dc.contributor.author Movahedi, K.
dc.contributor.author Van den Bergh, R.
dc.contributor.author Pereira-Fernandes, A.
dc.contributor.author Geuns, J. M.
dc.contributor.author Pircher, H.
dc.contributor.author Dorny, P.
dc.contributor.author Grooten, J.
dc.contributor.author De Baetselier, P.
dc.contributor.author Van Ginderachter, J. A.
dc.date.accessioned 2009-12-22T10:17:50Z
dc.date.available 2009-12-22T10:17:50Z
dc.date.issued 2009
dc.identifier.issn 0006-4971
dc.identifier.doi http://dx.doi.org/10.1182/blood-2009-05-221598
dc.identifier.other ITG-A11A
dc.identifier.other ANIMAL
dc.identifier.other U-ANIMAL
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other UPD17
dc.identifier.other ABSTRACT
dc.identifier.uri http://hdl.handle.net/10390/2882
dc.description.abstract Alternatively activated macrophages (AAMs), triggered by interleukin-4 (IL-4) and IL-13, play a modulating role during Th2 cytokine-driven pathologies, but their molecular armament remains poorly characterized. Here, we established E-cadherin (Cdh1) as a selective marker for IL-4/IL-13-exposed mouse and human macrophages, which is STAT6-dependently induced during polarized Th2 responses associated with Taenia crassiceps helminth infections or allergic airway inflammation. The IL-4-dependent, arginase-1/ornithine decarboxylase-mediated production of polyamines is important for maximal Cdh1 induction, unveiling a novel mechanism for IL-4-dependent gene transcription. At the macrophage surface, E-cadherin forms a functional complex with the catenins that accumulates at sites of cell contact. Macrophage-specific deletion of the Cdh1 gene illustrates the implication of E-cadherin in IL-4-driven macrophage fusion and heterotypic interactions with CD103(+) and KLRG1(+) T cells. This study identifies the E-cadherin/catenin complex as a discriminative, partly polyamine-regulated feature of IL-4/IL-13-exposed alternatively activated macrophages that contributes to homotypic and heterotypic cellular interactions. en
dc.language English en
dc.subject Macrophage activation en
dc.subject Interleukin-4 en
dc.subject Interleukin-13 en
dc.subject Markers en
dc.subject E-cadherin en
dc.title Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes en
dc.type Article en
dc.citation.issue 21 en
dc.citation.jtitle Blood en
dc.citation.volume 114 en
dc.citation.pages 4664-4674 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/19726720
dc.citation.jabbreviation Blood en


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