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A CATT negative result after treatment for human African trypanosomiasis is no indication for cure

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Show simple item record Lejon, V. Ngoyi, D. M. Boelaert, M. Büscher, P. 2010-02-09T09:20:12Z 2010-02-09T09:20:12Z 2010
dc.identifier.issn 1935-2727
dc.identifier.other ITG-P1A
dc.identifier.other ITG-H3A
dc.identifier.other ITG-PLA
dc.identifier.other MULTI
dc.identifier.other PARAS
dc.identifier.other U-SEROL
dc.identifier.other HEALTH
dc.identifier.other U-EPID
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other ELECTRONIC
dc.identifier.other UPD18
dc.identifier.other FTA
dc.identifier.other ABSTRACT
dc.description.abstract Background: cure after treatment for human African trypanosomiasis (HAT) is assessed by examination of the cerebrospinal fluid every 6 months, for a total period of 2 years. So far, no markers for cure or treatment failure have been identified in blood. Trypanosome-specific antibodies are detectable in blood by the Card Agglutination Test for Trypanosomiasis (CATT). We studied the value of a normalising, negative post-treatment CATT result in treated Trypanosoma brucei (T.b.) gambiense sleeping sickness patients as a marker of cure. Methodology/Principal Findings: the CATT/T.b. gambiense was performed on serum of a cohort of 360 T.b. gambiense patients, consisting of 242 primary and 118 retreatment cases. The CATT results during 2 years of post-treatment follow-up were studied in function of cure or treatment failure. At inclusion, sensitivity of CATT was 98% (234/238) in primary cases and only 78% (91/117) in retreatment cases. After treatment, the CATT titre decreased both in cured patients and in patients experiencing treatment failure. Conclusions/Significance: though CATT is a good test to detect HAT in primary cases, a normalising or negative CATT result after treatment for HAT does not indicate cure, therefore CATT cannot be used to monitor treatment outcome. en
dc.language English en
dc.subject Protozoal diseases en
dc.subject Trypanosomiasis, African en
dc.subject Trypanosoma brucei gambiense en
dc.subject Laboratory techniques and procedures en
dc.subject Card agglutination test en
dc.subject CATT en
dc.subject Sensitivity en
dc.subject Predictive value en
dc.subject Serum en
dc.subject Follow-up en
dc.subject Treatment outcome en
dc.subject Retreatment en
dc.subject Monitoring en
dc.title A CATT negative result after treatment for human African trypanosomiasis is no indication for cure en
dc.type Article-E en
dc.citation.issue 1 en
dc.citation.jtitle PLoS Neglected Tropical Diseases en
dc.citation.volume 4 en
dc.citation.pages e590 en
dc.citation.jabbreviation PLoS Negl Trop Dis en

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