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Effect of village-wide use of long-lasting insecticidal nets on visceral leishmaniasis vectors in India and Nepal: a cluster randomized trial

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dc.contributor.author Picado, A.
dc.contributor.author Das, M. L.
dc.contributor.author Kumar, V.
dc.contributor.author Kesari, S.
dc.contributor.author Dinesh, D. S.
dc.contributor.author Roy, L.
dc.contributor.author Rijal, S.
dc.contributor.author Das, P.
dc.contributor.author Rowland, M.
dc.contributor.author Sundar, S.
dc.contributor.author Coosemans, M.
dc.contributor.author Boelaert, M.
dc.contributor.author Davies, C. R.
dc.date.accessioned 2010-02-09T10:31:29Z
dc.date.available 2010-02-09T10:31:29Z
dc.date.issued 2010
dc.identifier.issn 1935-2727
dc.identifier.doi http://dx.doi.org/10.1371/journal.pntd.0000587
dc.identifier.other ITG-P11A
dc.identifier.other ITG-H12A
dc.identifier.other MULTI
dc.identifier.other PARAS
dc.identifier.other U-ENTOM
dc.identifier.other HEALTH
dc.identifier.other U-EPID
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other ELECTRONIC
dc.identifier.other UPD18
dc.identifier.other FTA
dc.identifier.other ABSTRACT
dc.identifier.uri http://hdl.handle.net/10390/2914
dc.description.abstract BACKGROUND: Visceral leishmaniasis (VL) control in the Indian subcontinent is currently based on case detection and treatment, and on vector control using indoor residual spraying (IRS). The use of long-lasting insecticidal nets (LN) has been postulated as an alternative or complement to IRS. Here we tested the impact of comprehensive distribution of LN on the density of Phlebotomus argentipes in VL-endemic villages. METHODS: A cluster-randomized controlled trial with household P. argentipes density as outcome was designed. Twelve clusters from an ongoing LN clinical trial-three intervention and three control clusters in both India and Nepal-were selected on the basis of accessibility and VL incidence. Ten houses per cluster selected on the basis of high pre-intervention P. argentipes density were monitored monthly for 12 months after distribution of LN using CDC light traps (LT) and mouth aspiration methods. Ten cattle sheds per cluster were also monitored by aspiration. FINDINGS: A random effect linear regression model showed that the cluster-wide distribution of LNs significantly reduced the P. argentipes density/house by 24.9% (95% CI 1.80%-42.5%) as measured by means of LTs. INTERPRETATION: The ongoing clinical trial, designed to measure the impact of LNs on VL incidence, will confirm whether LNs should be adopted as a control strategy in the regional VL elimination programs. The entomological evidence described here provides some evidence that LNs could be usefully deployed as part of the VL control program. TRIAL REGISTRATION: ClinicalTrials.gov CT-2005-015374. en
dc.language English en
dc.subject Protozoal diseases en
dc.subject Visceral en
dc.subject Leishmaniasis en
dc.subject Kala azar en
dc.subject Leishmania donovani en
dc.subject Vectors en
dc.subject Phlebotomus argentipes en
dc.subject Incidence en
dc.subject Control strategies en
dc.subject Vector control en
dc.subject Community-based distribution en
dc.subject Impregnated bednets en
dc.subject Insecticides en
dc.subject Effectiveness en
dc.subject Clusters en
dc.subject Impact en
dc.subject Density en
dc.subject Specimen collection en
dc.subject Entomology en
dc.subject Randomized clinical trials en
dc.subject India en
dc.subject Nepal en
dc.subject Asia, South en
dc.title Effect of village-wide use of long-lasting insecticidal nets on visceral leishmaniasis vectors in India and Nepal: a cluster randomized trial en
dc.type Article-E en
dc.citation.issue 1 en
dc.citation.jtitle PLoS Neglected Tropical Diseases en
dc.citation.volume 4 en
dc.citation.pages e587 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/20126269
dc.citation.jabbreviation PLoS Negl Trop Dis en


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