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Evaluation of host genetic and viral factors as surrogate markers for HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian HTLV-1-infected patients

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dc.contributor.author Talledo, M.
dc.contributor.author López, G.
dc.contributor.author Huyghe, J. R.
dc.contributor.author Verdonck, K.
dc.contributor.author Adaui, V.
dc.contributor.author González, E.
dc.contributor.author Best, I.
dc.contributor.author Clark, D.
dc.contributor.author Vanham, G.
dc.contributor.author Gotuzzo, E.
dc.contributor.author Van Camp, G.
dc.contributor.author Van Laer, L.
dc.date.accessioned 2010-02-11T08:31:03Z
dc.date.available 2010-02-11T08:31:03Z
dc.date.issued 2010
dc.identifier.issn 0146-6615
dc.identifier.doi http://dx.doi.org/10.1002/jmv.21675
dc.identifier.other ITG-M4B
dc.identifier.other ITG-M9A
dc.identifier.other MICRO
dc.identifier.other U-VIROL
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other UPD18
dc.identifier.other ABSTRACT
dc.identifier.uri http://hdl.handle.net/10390/2955
dc.description.abstract Human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a complication that affects up to 5% of HTLV-1-infected individuals. Several host genetic and viral factors have been associated with the risk of HAM/TSP. The aim of this study was to evaluate the performance of a prognostic model for HAM/TSP developed in Japan in a Peruvian population of 71 HAM/TSP patients and 94 asymptomatic carriers (ACs). This model included age, proviral load (PVL), the presence of HLA-A*02 and HLA-Cw*08 alleles, SDF-1 +801, and TNF-alpha -863 polymorphisms, and viral subgroup. We describe frequencies for the four host genetic markers and demonstrate the presence of the HTLV-1 tax B subgroup in Peru. Using cross-validation, we show that the predictive ability of the prognostic model, as characterized by the area under the receiver-operating characteristic curve (AUC), does not differ from a model containing PVL only (both AUC = 0.74). We found some suggestive evidence of a protective effect of the HLA-A*02 allele but failed to replicate the associations with the other three genetic markers and with viral subgroup. A logistic model containing PVL, age, gender, and HLA-A*02 provided the best predictive ability in the Peruvian cohort (AUC = 0.79). en
dc.language English en
dc.subject Viral diseases en
dc.subject HTLV-1 en
dc.subject Myelopathy en
dc.subject Spastic paraparesis en
dc.subject Surrogate markers en
dc.subject Genetic predisposition to disease en
dc.subject Genotypes en
dc.subject Alleles en
dc.subject Prediction en
dc.subject Evaluation en
dc.subject Models en
dc.subject Peru en
dc.subject America, Latin en
dc.title Evaluation of host genetic and viral factors as surrogate markers for HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian HTLV-1-infected patients en
dc.type Article en
dc.citation.issue 3 en
dc.citation.jtitle Journal of Medical Virology en
dc.citation.volume 82 en
dc.citation.pages 460-466 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/20087941
dc.citation.jabbreviation J Med Virol en


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