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Usefulness of the Plasmodium falciparum chloroquine resistance transporter T76 genotype failure index for the estimation of in vivo chloroquine resistance in Burkina Faso

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dc.contributor.author Tinto, H. en_US
dc.contributor.author Sanou, B. en_US
dc.contributor.author Dujardin, J. C. en_US
dc.contributor.author Ouédraogo, J. B. en_US
dc.contributor.author Van Overmeir, C. en_US
dc.contributor.author Erhart, A. en_US
dc.contributor.author Van Marck, E. en_US
dc.contributor.author Guiguemdé, T. R. en_US
dc.contributor.author D'Alessandro, U. en_US
dc.date.accessioned 2007-12-06T14:34:17Z
dc.date.available 2007-12-06T14:34:17Z
dc.date.issued 2005 en_US
dc.identifier.issn 0002-9637 en_US
dc.identifier.other ITG-P3A en_US
dc.identifier.other ITG-P5B en_US
dc.identifier.other ITG-P6A en_US
dc.identifier.other ITG-PLA en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-MALAR en_US
dc.identifier.other U-PROTO en_US
dc.identifier.other JIF en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.other URL
dc.identifier.uri http://hdl.handle.net/10390/302
dc.description.abstract The prevalence of chloroquine (CQ) treatment failure and the genotype failure index was determined in four sentinel sites in Burkina Faso. In three sites, the genotype failure index varied between 1.7 and 3, a result confirming the relationship between the Plasmodium falciparum CQ resistance transporter (Pfcrt) T76 mutation and CQ resistance. In the remaining site, the genotype failure index was unusually low, 1.1, which was significantly different than that in the other sites (P < 0.00001). These findings are discussed. Often but not always, the prevalence of CQ resistance can be correctly estimated by the Pfcrt T76 genotype failure index. en_US
dc.language English en_US
dc.subject Protozoal diseases en_US
dc.subject Malaria en_US
dc.subject Chloroquine en_US
dc.subject Drug resistance en_US
dc.subject Surveillance en_US
dc.subject Molecular markers en_US
dc.subject Polymorphism en_US
dc.subject Mutations en_US
dc.subject Pfcrt en_US
dc.subject Sensitivity en_US
dc.subject Burkina Faso en_US
dc.subject Africa, West en_US
dc.title Usefulness of the Plasmodium falciparum chloroquine resistance transporter T76 genotype failure index for the estimation of in vivo chloroquine resistance in Burkina Faso en_US
dc.type Article en_US
dc.citation.issue 1 en_US
dc.citation.jtitle American Journal of Tropical Medicine and Hygiene en_US
dc.citation.volume 73 en_US
dc.citation.pages 171-173 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/16014853
dc.identifier.url http://www.ajtmh.org/cgi/reprint/73/1/171.pdf
dc.citation.jabbreviation Am J Trop Med Hyg en_US


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