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Sensibilité in vivo de Plasmodium falciparum à la chloroquine et à la sulfadoxine-pyriméthamine dans la région de Bobo Dioulasso (1998-2001): étude des facteurs de risque associés aux échecs thérapeutiques de ces deux médicaments

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dc.contributor.author Tinto, H. en_US
dc.contributor.author Sanou, B. en_US
dc.contributor.author Erhart, A. en_US
dc.contributor.author D'Alessandro, U. en_US
dc.contributor.author Ouédraogo, J. B. en_US
dc.contributor.author Guiguemdé, T. R. en_US
dc.date.accessioned 2007-12-06T14:34:17Z
dc.date.available 2007-12-06T14:34:17Z
dc.date.issued 2006 en_US
dc.identifier.issn 0037-9085 en_US
dc.identifier.other ITG-P1B en_US
dc.identifier.other ITG-P3A en_US
dc.identifier.other ITG-P4A en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-MALAR en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/303
dc.description.abstract The therapeutic efficacy of chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) was determined over a 4 year period (1998-2001) in Bobo Dioulasso, Burkina Faso, with an analysis of the risk factors associated to treatment failures to the 2 drugs. In total, 2008 children (6 months-15 years old) attending in 4 health centres (1 urban and 3 rural) were included in the study. Children were alternatively allocated to either CQ or SP The WHO 14-days in vivo field test was carried out. PCV was measured at day 0 and 14. CQ treatment failure was 24.4% (229/940), most of them being late failures. Between 1998 and 2001 a significant increase in CQ treatment failure (p < 0.001) was observed. SP showed a good efficacy with a total treatment failure of 4.4% (33/749). However; a significant increase of resistance to this drug (p=0.001) was also observed between 1998 and 2001. Among children with anaemia at day 0.85% (23/27) were no more anaemic by day 14 in the SP group, while in the CQ group the proportion was lower; 69% (27/39). However the difference between the two drugs was not significant (p > 0.1). Univariate analysis showed that the site, the age of children, the time of recruitment and the parasitaemia were significantly associated with CQ treatment failure. In the multivariate analysis these 4 variables remain significantly and independently associated with the risk of CQ treatment failure. After adjusting for the effect of the 3 other factors, the risk of treatment failure was reduced by half in rural area compared to urban area as well as in children of 5-15 years of age compared to those under 5. The risk of treatment failure was significantly increased in 2000-2001 (OR = 1.66, p < 0.05) as compared to the 2 previous years (1998-1999). It was also twice higher in children with parasitaemia > or = 16,000/microl than in those having a lower parasitaemia. For SP we have not observed such connexions with the univariate and multivariate analysis. en_US
dc.language French en_US
dc.subject Protozoal diseases en_US
dc.subject Malaria en_US
dc.subject Antimalarials en_US
dc.subject Chloroquine en_US
dc.subject Sulfadoxine-pyrimethamine en_US
dc.subject Treatment outcomes en_US
dc.subject Drug resistance en_US
dc.subject Risk factors en_US
dc.subject Burkina Faso en_US
dc.subject Africa, West en_US
dc.title Sensibilité in vivo de Plasmodium falciparum à la chloroquine et à la sulfadoxine-pyriméthamine dans la région de Bobo Dioulasso (1998-2001): étude des facteurs de risque associés aux échecs thérapeutiques de ces deux médicaments fr
dc.type Article en_US
dc.citation.issue 3 en_US
dc.citation.jtitle Bulletin de la Société de Pathologie Exotique fr
dc.citation.volume 99 en_US
dc.citation.pages 161-165 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/16983817
dc.citation.jabbreviation Bull Soc Pathol Exot fr


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