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Associations between specific antibody responses and resistance to reinfection in a Senegalese population recently exposed to Schistosoma mansoni

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dc.contributor.author Vereecken, K. en_US
dc.contributor.author Naus, C. W. A. en_US
dc.contributor.author Polman, K. en_US
dc.contributor.author Scott, J. T. en_US
dc.contributor.author Diop, M. en_US
dc.contributor.author Gryseels, B. en_US
dc.contributor.author Kestens, L. en_US
dc.date.accessioned 2007-12-06T14:34:30Z
dc.date.available 2007-12-06T14:34:30Z
dc.date.issued 2007 en_US
dc.identifier.issn 1360-2276 en_US
dc.identifier.doi http://dx.doi.org/10.1111/j.1365-3156.2006.01805.x
dc.identifier.other ITG-P1B en_US
dc.identifier.other ITG-P2B en_US
dc.identifier.other ITG-P3A en_US
dc.identifier.other ITG-P4B en_US
dc.identifier.other ITG-P6A en_US
dc.identifier.other ITG-MLA en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-SCHISTO en_US
dc.identifier.other MICRO en_US
dc.identifier.other U-IMMUN en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.other MULTI en_US
dc.identifier.other DIREC en_US
dc.identifier.other FTB
dc.identifier.uri http://hdl.handle.net/10390/342
dc.description The definitive version is available at www3.interscience.wiley.com
dc.description.abstract We examined associations between schistosome-specific antibody responses and reinfection in Senegalese individuals recently exposed to Schistosoma mansoni. The effects of treatment, age, intensity of infection and duration of exposure on schistosome-specific antibody responses were also investigated by comparing immune responses in individuals exposed for less than 3 years with responses in people exposed for more than 8 years. All individuals were bled before treatment as well as 6 and 12 weeks after. We used a statistical model that included interaction terms between time, age, infection intensity and duration of exposure. The overall patterns of most specific antibody responses by age were similar to those previously published for S. mansoni, Schistosoma japonicum and Schistosoma haematobium infections in different endemic areas. In general, a boost in specific antibody responses against adult worm antigen (SWA) was observed at 6 weeks after treatment whereas the majority of isotype responses against egg antigen (SEA) were not affected by treatment. Our analysis showed that the effect of treatment on schistosome-specific antibody responses is influenced by age, infection intensity and duration of exposure. We found no evidence that treatment matures the specific antibody response of children recently infected with S. mansoni. Our results indicate that the build-up of potentially protective immunoglobulin E (IgE) responses was associated with duration of exposure, or, in other words, experience of infection. Interestingly, in recently exposed individuals there was a significant association between IgA responses to SWA and resistance to reinfection. Resistance to reinfection and production of IgA-SWA was associated with adulthood independently of exposure patterns, suggesting that susceptibility to S. mansoni and the development of protective immune responses is age-dependent. en_US
dc.language English en_US
dc.publisher Blackwell Publishing
dc.subject Helminthic diseases en_US
dc.subject Schistosomiasis en_US
dc.subject Schistosoma mansoni en_US
dc.subject Immune response en_US
dc.subject Antibodies en_US
dc.subject Exposure en_US
dc.subject Age factors en_US
dc.subject Disease resistance en_US
dc.subject Disease susceptibility en_US
dc.subject Reinfection en_US
dc.subject Senegal en_US
dc.subject Africa, West en_US
dc.title Associations between specific antibody responses and resistance to reinfection in a Senegalese population recently exposed to Schistosoma mansoni en_US
dc.type Article en_US
dc.citation.issue 3 en_US
dc.citation.jtitle Tropical Medicine and International Health en_US
dc.citation.volume 12 en_US
dc.citation.pages 431-444 en_US
dc.publisher.place Oxford
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/17313515
dc.citation.jabbreviation Trop Med Int Health en_US


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