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The challenge of diagnosing atopic diseases: outcomes in Cuban children depend on definition and methodology

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dc.contributor.author Wördemann, M. en_US
dc.contributor.author Polman, K. en_US
dc.contributor.author Diaz, R. J. en_US
dc.contributor.author Menocal Heredia, L. T. en_US
dc.contributor.author Madurga, A. M. C. en_US
dc.contributor.author Sague, K. A. en_US
dc.contributor.author Gryseels, B. en_US
dc.contributor.author Gorbea, M. B. en_US
dc.date.accessioned 2007-12-06T14:34:34Z
dc.date.available 2007-12-06T14:34:34Z
dc.date.issued 2006 en_US
dc.identifier.issn 0105-4538 en_US
dc.identifier.doi http://dx.doi.org/10.1111/j.1398-9995.2006.01129.x
dc.identifier.other ITG-P1A en_US
dc.identifier.other ITG-P2A en_US
dc.identifier.other ITG-P7A en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-SCHISTO en_US
dc.identifier.other DIREC en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/354
dc.description.abstract BACKGROUND: Prevalences of childhood asthma and other atopic diseases are increasing worldwide, and so is the number of diagnostic methods and definitions used. We determined the occurrence of atopic diseases in Cuban children with a range of diagnostic approaches commonly used or proposed in epidemiological studies, and compared the different outcome measures. METHODS: A total of 398 Cuban schoolchildren between 5 and 13 years of age were diagnosed by International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire, clinical examination, pre- and post-exercise spirometry, and skin prick testing. All results were considered separately, as well as jointly by using scores and definitions as described in the literature. RESULTS: Using questionnaire-based approaches, 21-39% of the children were positive for asthma, 9-19% for atopic dermatitis, and 15-46% for rhinoconjunctivitis. With spirometry, 7% of the children had asthma. Definitions based on a combination of questionnaire and spirometry results yielded asthma rates of 5%. Of all children, 6% wheezed on clinical examination, and only one child showed clinical signs of atopic dermatitis. Eleven percent of the children had a positive skin prick test. In total, 254 children (64%) had an atopic disease as based on the ISAAC questionnaire, and 263 (66%) based on all approaches used. CONCLUSION: Diagnostic outcomes on atopic diseases vary considerably depending on definition and methodology. Our results clearly demonstrate the need for consensus on diagnosing asthma and other atopic diseases in epidemiological studies. Based on the most commonly used ISAAC questionnaire, our data suggest prevalences of atopic diseases in Cuban children that rival those found in some other Latin American countries and developed nations with the highest prevalences in the world. en_US
dc.language English en_US
dc.subject Asthma en_US
dc.subject Dermatitis, atopic en_US
dc.subject Rhinoconjunctivitis en_US
dc.subject Clinical diagnosis en_US
dc.subject Case definition en_US
dc.subject Epidemiology en_US
dc.subject Prevalence en_US
dc.subject Cuba en_US
dc.subject Caribbean en_US
dc.subject America, Latin en_US
dc.title The challenge of diagnosing atopic diseases: outcomes in Cuban children depend on definition and methodology en_US
dc.type Article en_US
dc.citation.issue 9 en_US
dc.citation.jtitle Allergy en_US
dc.citation.volume 61 en_US
dc.citation.pages 1125-1131 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/16918517
dc.citation.jabbreviation Allergy en_US


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