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Exposure, infection and immune responses to Schistosoma haematobium in young children

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dc.contributor.author Woolhouse, M. E. J. en_US
dc.contributor.author Mutapi, F. en_US
dc.contributor.author Ndhlovu, P. D. en_US
dc.contributor.author Chandiwana, S. K. en_US
dc.contributor.author Hagan, P. en_US
dc.date.accessioned 2007-12-06T14:34:35Z
dc.date.available 2007-12-06T14:34:35Z
dc.date.issued 2000 en_US
dc.identifier.issn 0031-1820 en_US
dc.identifier.doi http://dx.doi.org/10.1017/S0031182099005156
dc.identifier.other ITG-P2B en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-SCHISTO en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other FTA en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/357
dc.description.abstract Behavioural, parasitological and immunological data were obtained from 48 children up to 6 years old, resident in a Schistosoma haematobium endemic area in Zimbabwe. The children averaged more than 1 contact with infective water bodies every 3 days and all showed immunological evidence of exposure (an anti-cercarial and/or anti-egg antibody response). IgM was the dominant isotype and appeared in the youngest children, followed by IgA, IgE and IgG3. However, only 38 children showed evidence of infection (an anti-egg response or eggs in urine) and only 14 were excreting eggs. The best estimates from these data are that less than 1 in 100 contacts results in infection and less than 1 in 1000 result in egg output. This suggests that there may be substantial attrition of invading cercaria even in naïve individuals. en_US
dc.language English en_US
dc.publisher Cambridge University Press en_US
dc.subject Helminthic diseases en_US
dc.subject Schistosoma haematobium en_US
dc.subject Immunity en_US
dc.subject Children en_US
dc.title Exposure, infection and immune responses to Schistosoma haematobium in young children en_US
dc.type Article en_US
dc.citation.jtitle Parasitology en_US
dc.citation.volume 120 en_US
dc.citation.pages 37-44 en_US
dc.publisher.place Cambridge en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/10726264
dc.citation.jabbreviation Parasitology en_US


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