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Classification of sporadic Creutzfeldt-jacob disease based on clinical and neuropathological characteristics

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dc.contributor.author Abrahantes, J. C. en_US
dc.contributor.author Aerts, M. en_US
dc.contributor.author van Everbroeck, B. en_US
dc.contributor.author Saegerman, C. en_US
dc.contributor.author Berkvens, D. en_US
dc.contributor.author Geys, H. en_US
dc.contributor.author Mintiens, K. en_US
dc.contributor.author Roels, S. en_US
dc.contributor.author Cras, P. en_US
dc.date.accessioned 2007-12-06T14:35:38Z
dc.date.available 2007-12-06T14:35:38Z
dc.date.issued 2007 en_US
dc.identifier.issn 0393-2990 en_US
dc.identifier.doi http://dx.doi.org/10.1007/s10654-007-9146-x
dc.identifier.other ITG-A5A en_US
dc.identifier.other ANIMAL en_US
dc.identifier.other U-ANIMAL en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/407
dc.description.abstract Creutzfeldt-Jakob disease (CJD) is a rare and fatal neurodegenerative disease of unknown cause. Patients are usually aged between 50 and 75 and typical clinical features include rapidly progressive dementia associated with myoclonus and a characteristic electroencephalographic pattern. Neuropathological examination reveals cortical spongiform change, hence the term 'spongiform encephalopathy'. Several statistical techniques were applied to classify patients with sporadic CJD (sCJD), based on clinical and neuropathological investigation. We focus on the classification of neuropathologically confirmed sCJD patients. In order to obtain a classification rule that correctly classifies this type of patients and at the same time controls the overall error rate, we apply several classification techniques, which in general, produce comparable results. The boosting method produces the best results and the variable 14-3-3 protein in cerebrospinal fluid plays the most important role in the prediction of neuropathologically confirmed sCJD. en_US
dc.language English en_US
dc.subject Prion diseases en_US
dc.subject Creutzfeldt-Jacob syndrome en_US
dc.subject Spongiform encephalopathy en_US
dc.subject Disease classification en_US
dc.subject Criteria en_US
dc.title Classification of sporadic Creutzfeldt-jacob disease based on clinical and neuropathological characteristics en_US
dc.type Article en_US
dc.citation.issue 7 en_US
dc.citation.jtitle European Journal of Epidemiology en_US
dc.citation.volume 22 en_US
dc.citation.pages 457-465 en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/17587185
dc.citation.jabbreviation Eur J Epidemiol en_US


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