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Drug resistance in human helminths: current situation and lessons from livestock

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dc.contributor.author Geerts, S. en_US
dc.contributor.author Gryseels, B. en_US
dc.date.accessioned 2007-12-06T14:36:11Z
dc.date.available 2007-12-06T14:36:11Z
dc.date.issued 2000 en_US
dc.identifier.issn 0893-8512 en_US
dc.identifier.other ITG-A1A en_US
dc.identifier.other ITG-PLA en_US
dc.identifier.other ANIMAL en_US
dc.identifier.other U-ANIMAL en_US
dc.identifier.other PARAS en_US
dc.identifier.other U-SCHISTO en_US
dc.identifier.other MULTI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.other JIF en_US
dc.identifier.other FTC
dc.identifier.uri http://hdl.handle.net/10390/512
dc.description.abstract We briefly review reports on drug resistance in human helminths and compare the factors which contribute to the development of anthelmintic resistance in livestock and man, i.e. high treatment frequency, single-drug regimens, targeting and timing of mass treatments and underdosing. Conclusions are drawn from the mistakes in the treatment and control of livestock helminths. The advantages and inconveniences of current methods for the detection of drug resistance in helminths of livestock are discussed and some suggestions are put forward to standardize the tests for the detection of resistance in human helminths. Finally, based on veterinary experience, some recommendations are made to reduce the risks of development of drug resistance in human helminths. The dramatic and rapid spread of resistance to all major classes of veterinary anthelmintics should be a warning against too strong a reliance on drugs in helminth control programmes. en_US
dc.language English en_US
dc.publisher American Society for Microbiology en_US
dc.subject Helminthic diseases en_US
dc.subject Human en_US
dc.subject Livestock en_US
dc.subject Drug resistance en_US
dc.subject Contributing factors en_US
dc.subject Mechanisms en_US
dc.subject Genetics en_US
dc.subject Detection en_US
dc.subject Tests en_US
dc.subject Laboratories en_US
dc.title Drug resistance in human helminths: current situation and lessons from livestock en_US
dc.type Article en_US
dc.citation.issue 1 en_US
dc.citation.jtitle Clinical Microbiology Reviews en_US
dc.citation.volume 13 en_US
dc.citation.pages 207-222 en_US
dc.publisher.place Washington en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/11703846
dc.citation.jabbreviation Clin Microbiol Rev en_US


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