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Immunogenetic influences on tick resistance in African cattle with particular reference to trypanotolerant N'Dama (Bos taurus) and trypanosusceptible Gobra zebu (Bos indicus) cattle

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dc.contributor.author Mattioli, R. C. en_US
dc.contributor.author Pandey, V. S. en_US
dc.contributor.author Murray, M. en_US
dc.contributor.author Fitzpatrick, J. L. en_US
dc.date.accessioned 2007-12-06T14:36:30Z
dc.date.available 2007-12-06T14:36:30Z
dc.date.issued 2000 en_US
dc.identifier.issn 0001-706X en_US
dc.identifier.doi http://dx.doi.org/10.1016/S0001-706X(00)00063-2
dc.identifier.other ITG-A2A en_US
dc.identifier.other ANIMAL en_US
dc.identifier.other U-ANIMAL en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/571
dc.description.abstract In sub-Saharan Africa, tick infestation and tick-borne infections together with tsetse-transmitted trypanosomosis arguably constitute the main parasitological disease complex constraining livestock production. Resistance to tick attack and tick-borne micro-organisms (TBMs) varies among different breeds of cattle. The magnitude of losses due to these parasites is related to an extent to the degree of breed resistance. Generally, zebu (Bos indicus) cattle possess a higher resistance to ticks and TBMs than European (Bos taurus) cattle. The host's immune system would appear to be the single most important factor that regulates this resistance. This paper reports on the main effector immune mechanisms governing resistance against ticks and TBMs. The cellular immune response appears more effective and stable than humoral immunity in modulating resistance to ticks and TBMs. Similarities between the immune mechanisms employed by trypanotolerant N'Dama (B. taurus) cattle, when infected with trypanosomes, and those elicited by tick bites and TBMs seem to exist, particularly at the skin level in the early phases of parasitic invasion. Moreover, there is evidence that in the N'Dama breed, resistance against ticks per se also has a genetic basis. Therefore, the N'Dama appears to be a unique breed in that it exhibits resistance to several parasitic diseases and/or infections, including helminths, when compared to other cattle breeds in West Africa. It is concluded that the multi-parasite resistant traits of the N'Dama breed should be exploited in those areas where trypanosomosis, ticks and tick-borne diseases constrain animal production. This should be of benefit for low-input farming systems where the use of chemicals for prophylaxis and therapy is limited by their relatively high cost. Additionally, the potential contribution of multiple disease resistant N'Dama cattle should be considered in crossbreeding programmes with exotic dairy breeds for increasing milk production in West Africa. en_US
dc.language English en_US
dc.publisher Elsevier
dc.subject Protozoal diseases en_US
dc.subject Trypanosomiasis en_US
dc.subject Animal diseases en_US
dc.subject Trypanotolerance en_US
dc.subject Genetics en_US
dc.subject N'Dama en_US
dc.subject Zebus en_US
dc.subject Africa en_US
dc.title Immunogenetic influences on tick resistance in African cattle with particular reference to trypanotolerant N'Dama (Bos taurus) and trypanosusceptible Gobra zebu (Bos indicus) cattle en_US
dc.type Article en_US
dc.citation.issue 3 en_US
dc.citation.jtitle Acta Tropica en_US
dc.citation.volume 75 en_US
dc.citation.pages 263-277 en_US
dc.publisher.place Amsterdam
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/10838210
dc.identifier.url http://www.elsevier.com/wps/product/cws_home/506043
dc.citation.jabbreviation Acta Trop en_US


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