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Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon

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dc.contributor.author Assana, E.
dc.contributor.author Kyngdon, C. T.
dc.contributor.author Gauci, C. G.
dc.contributor.author Geerts, S.
dc.contributor.author Dorny, P.
dc.contributor.author De Deken, R.
dc.contributor.author Anderson, G. A.
dc.contributor.author Zoli, A. P.
dc.contributor.author Lightowlers, M. W.
dc.date.accessioned 2010-04-21T09:14:39Z
dc.date.available 2010-04-21T09:14:39Z
dc.date.issued 2010
dc.identifier.issn 0020-7519
dc.identifier.doi http://dx.doi.org/10.1016/j.ijpara.2010.01.006
dc.identifier.other ITG-A1B
dc.identifier.other ITG-A4A
dc.identifier.other ITG-A5A
dc.identifier.other ITG-A6A
dc.identifier.other ANIMAL
dc.identifier.other U-ANIMAL
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other UPD20
dc.identifier.other ABSTRACT
dc.identifier.uri http://hdl.handle.net/10390/6105
dc.description.abstract A pilot field trial of the TSOL18 vaccine was undertaken in Cameroon. Two hundred and forty, 2-3 month-old piglets were distributed to 114 individual households in pairs. Vaccinated animals received three immunisations with 200 microg TSOL18 plus 5 mg Quil A and 30 mg/kg oxfendazole at the time of the second immunisation. Necropsies were undertaken when the pigs were approximately 12 months of age. Viable Taenia solium cysticerci were identified in 20 control pigs (prevalence 19.6%); no cysticerci were found in any of the vaccinated animals (P<0.0001). Combined application of TSOL18 vaccination and a single oxfendazole treatment in pigs may be a relatively simple and sustainable procedure that has the potential to control T. solium transmission in endemic areas and, indirectly, reduce the number of new cases of neurocysticercosis in humans. 2010 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved. en
dc.language English en
dc.subject Helminthic diseases en
dc.subject Animal diseases en
dc.subject Taeniasis en
dc.subject Neurocysticercosis en
dc.subject Taenia solium en
dc.subject Cestodes en
dc.subject Hosts en
dc.subject Pigs en
dc.subject Field trials en
dc.subject Vaccine trial en
dc.subject Control en
dc.subject Vaccination en
dc.subject Oxfendazol en
dc.subject Cameroon en
dc.subject Africa, Central en
dc.title Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon en
dc.type Article en
dc.citation.issue 5 en
dc.citation.jtitle International Journal for Parasitology en
dc.citation.volume 40 en
dc.citation.pages 515-519 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/20138046
dc.citation.jabbreviation Int J Parasitol en


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