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Population-level retrospective study of neurologically expressed disorders in ruminants before the onset of bovine spongiform encephalopathy (BSE) in Belgium, a BSE risk III country

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dc.contributor.author Saegerman, C. en_US
dc.contributor.author Berkvens, D. en_US
dc.contributor.author Claes, L. en_US
dc.contributor.author Dewaele, A. en_US
dc.contributor.author Coignoul, F. en_US
dc.contributor.author Ducatelle, R. en_US
dc.contributor.author Cassart, D. en_US
dc.contributor.author Brochier, B. en_US
dc.contributor.author Costy, F. en_US
dc.contributor.author Roels, S. en_US
dc.contributor.author Deluyker, H. en_US
dc.contributor.author Vanopdenbosch, E. en_US
dc.contributor.author Thiry, E. en_US
dc.date.accessioned 2007-12-06T14:36:43Z
dc.date.available 2007-12-06T14:36:43Z
dc.date.issued 2005 en_US
dc.identifier.issn 0095-1137 en_US
dc.identifier.doi http://dx.doi.org/10.1128/JCM.43.2.862-869.2005
dc.identifier.other ITG-A2A en_US
dc.identifier.other ANIMAL en_US
dc.identifier.other U-ANIMAL en_US
dc.identifier.other JIF en_US
dc.identifier.other DOI en_US
dc.identifier.other ABSTRACT en_US
dc.identifier.uri http://hdl.handle.net/10390/610
dc.description.abstract A retrospective epidemiological study (n = 7,875) of neurologically expressed disorders (NED) in ruminants before the onset of the bovine spongiform encephalopathy epidemic (years studied, 1980 to 1997) was carried out in Belgium. The archives of all veterinary laboratories and rabies and transmissible spongiform encephalopathy (TSE) epidemiosurveillance networks were consulted. For all species, a significantly higher number of NED with virological causes (rabies) was reported south of the Sambre-Meuse Valley. During the period 1992 to 1997, for which the data were complete, (i) the predicted annual incidence of NED varied significantly as a function of species and area (higher numbers in areas where rabies was present) but was always above 100 cases per million, and (ii) the mean incidence of suspected TSE cases and, among them, those investigated by histopathological examination varied significantly as a function of species and area. The positive predictive value of a presumptive clinical diagnosis of NED ranged from 0.13 (game) to 0.63 (sheep). Knowledge of the positive predictive value permits the definition of a reference point before certain actions (e.g., awareness and training campaigns) are undertaken. It also shows the usefulness of a systematic necropsy or complementary laboratory tests to establish an etiological diagnosis. TSE analysis of a small, targeted historical sampling (n = 48) permitted the confirmation of one case and uncovered another case of scrapie. The results of the present study help to develop and maintain the quality of the worldwide clinical epidemiological networks for TSE, especially in countries that in the past imported live animals, animal products, and feedstuffs from countries with TSE cases. en_US
dc.language English en_US
dc.publisher American Society for Microbiology en_US
dc.subject Animal diseases en_US
dc.subject Prion diseases en_US
dc.subject Bovine spongiform encephalopathy en_US
dc.subject BSE en_US
dc.subject Neurologic disorders en_US
dc.subject Incidence en_US
dc.subject Regional differences en_US
dc.subject Predictive value en_US
dc.subject Belgium en_US
dc.subject Europe, West en_US
dc.title Population-level retrospective study of neurologically expressed disorders in ruminants before the onset of bovine spongiform encephalopathy (BSE) in Belgium, a BSE risk III country en_US
dc.type Article en_US
dc.citation.issue 2 en_US
dc.citation.jtitle Journal of Clinical Microbiology en_US
dc.citation.volume 43 en_US
dc.citation.pages 862-869 en_US
dc.publisher.place Washington en_US
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/15695693
dc.citation.jabbreviation J Clin Microbiol en_US


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