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Circulating anodic antigen levels in two areas endemic for schistosomiasis mansoni indicate differences in worm fecundity

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dc.contributor.author van Lieshout, L.
dc.contributor.author Polman, K.
dc.contributor.author Gryseels, B.
dc.contributor.author Deelder, A. M.
dc.date.accessioned 2010-05-20T12:14:42Z
dc.date.available 2010-05-20T12:14:42Z
dc.date.issued 1998
dc.identifier.issn 0035-9203
dc.identifier.other ITG-S2A
dc.identifier.other ITG-D3A
dc.identifier.other DIRECT
dc.identifier.other U-SCHISTO
dc.identifier.other JIF
dc.identifier.other ABSTRACT
dc.identifier.uri http://hdl.handle.net/10390/6158
dc.description.abstract Serum levels of the adult schistosome circulating anodic antigen (CAA) were compared in 2 populations, both living in an area with extremely high transmission levels of Schistosoma mansoni. In one focus (Maniema, eastern Zaire) transmission has been established for several decades, while in the other focus (Ndombo, northern Senegal) transmission started only recently. While parasite egg counts in the 2 populations were virtually similar, including analogous age-related distributions, serum levels of CAA were approximately 5 times higher in the chronically exposed community. This difference in antigen level was most pronounced in adolescents and adults. As the level of CAA is assumed to be a direct reflection of worm burden, these findings suggest higher parasite fecundity in the recently exposed community. It is not very likely that these observations could be explained solely by differences in clearance mechanisms caused by a variation in experience of infection. The relationship between circulating antigen levels and egg counts was consistent for all age groups in the Maniema population, while in the Ndombo population only children showed a pattern similar to that in the chronically exposed community. en
dc.language English en
dc.subject Helminthic diseases en
dc.subject Schistosomiasis en
dc.subject Schistosoma mansoni en
dc.subject Circulating antigens en
dc.subject Congo-Kinshasa en
dc.subject Maniema en
dc.subject Africa, Central en
dc.subject Senegal en
dc.subject Africa, West en
dc.title Circulating anodic antigen levels in two areas endemic for schistosomiasis mansoni indicate differences in worm fecundity en
dc.type Article en
dc.citation.issue 1 en
dc.citation.jtitle Transactions of the Royal Society of Tropical Medicine and Hygiene en
dc.citation.volume 92 en
dc.citation.pages 115-119 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/9692172
dc.citation.jabbreviation Trans R Soc Trop Med Hyg en


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