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The contribution of host-related factors to low cure rates of praziquantel for the treatment of Schistosoma mansoni in Senegal

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Show simple item record van Lieshout, L. Stelma, F. F. Guissé, F. Falcao Ferreira, S. T. M. Polman, K. Van Dam, G. J. Diakhaté, M. M. Sow, S. Deelder, A. Gryseels, B. 2010-05-20T14:19:21Z 2010-05-20T14:19:21Z 1999
dc.identifier.issn 0002-9637
dc.identifier.other ITG-S5A
dc.identifier.other ITG-S8A
dc.identifier.other ITG-DLA
dc.identifier.other DIRECT
dc.identifier.other U-SCHISTO
dc.identifier.other JIF
dc.identifier.other ABSTRACT
dc.description.abstract Surprisingly low cure rates were repeatedly observed after treatment with a standard dosage of praziquantel in a recently established Schistosoma mansoni focus in northern Senegal. In 4 discrete cohorts from the same population, cure rates were 18-36% and egg count reduction rates were 77-88%. Data and material of 920 compliant subjects from all 4 cohorts were further analyzed to identify possible host-related factors associated with low cure rates. The lowest cure rates were found in the highest egg count groups. However, in low and moderate egg count groups, drug efficacy was also below normal values. Cure rates were similar in males and females, showed no seasonal variation, and were independent of previous praziquantel treatment. They were significantly higher in adults than in children, also after allowing for intensity of infection. Individual water contact behavior and specific humoral immune responses were examined in 2 extreme subgroups, either without significant egg count reduction or showing complete parasitologic cure. There was no significant difference in frequency and duration of water contact between those individuals with complete cure and those that showed little effect of praziquantel treatment. Levels of IgG, IgG1, IgG3, IgG4, IgM, and IgE against adult worm antigen were not different between the 2 subgroups. Thus, the abnormally frequent failure of treatment observed in this focus could not be associated with any host-related factor, other than age and pretreatment egg counts. en
dc.language English en
dc.subject Helminthic diseases en
dc.subject Schistosomiasis en
dc.subject Schistosoma mansoni en
dc.subject Treatment en
dc.subject Praziquantel en
dc.subject Senegal en
dc.subject Africa, West en
dc.title The contribution of host-related factors to low cure rates of praziquantel for the treatment of Schistosoma mansoni in Senegal en
dc.type Article en
dc.citation.issue 5 en
dc.citation.jtitle American Journal of Tropical Medicine and Hygiene en
dc.citation.volume 61 en
dc.citation.pages 760-765 en
dc.citation.jabbreviation Am J Trop Med Hyg en

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