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First evidence of high knockdown resistance frequency in Anopheles arabiensis (Diptera: Culicidae) from Ethiopia

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dc.contributor.author Yewhalaw, D.
dc.contributor.author Van Bortel, W.
dc.contributor.author Denis, L.
dc.contributor.author Coosemans, M.
dc.contributor.author Duchateau, L.
dc.contributor.author Speybroeck, N.
dc.date.accessioned 2010-08-06T09:26:37Z
dc.date.available 2010-08-06T09:26:37Z
dc.date.issued 2010
dc.identifier.issn 0002-9637
dc.identifier.doi http://dx.doi.org/10.4269/ajtmh.2010.09-0738
dc.identifier.other ITG-P2A
dc.identifier.other ITG-P3B
dc.identifier.other ITG-P4A
dc.identifier.other ITG-ALA
dc.identifier.other MULTI
dc.identifier.other PARAS
dc.identifier.other U-ENTOM
dc.identifier.other ANIMAL
dc.identifier.other U-ANIMAL
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other Abstract
dc.identifier.other UPD23
dc.identifier.uri http://hdl.handle.net/10390/6238
dc.description.abstract The status of knockdown resistance (kdr) mutation was investigated in the major malaria vector Anopheles arabiensis Patton (Diptera: Culicidae) from Ethiopia. Among 240 mosquito samples from 15 villages of southwestern Ethiopia that were screened by allele-specific polymerase chain reaction for kdr mutations, the West African kdr mutation (L1014F) was detected in almost all specimens (98.5%), whereas the East African kdr mutation (L1014S) was absent. Moreover, the mortality of An. gambiae s.l. to diagnostic dosages of 4% DDT, 0.75% permethrin, and 0.05% deltamethrin from bioassay results was 1.0%, 18.1%, and 82.2%, respectively. We report here the highest kdr allele frequency ever observed in An. arabiensis and its implications in malaria vector control in Ethiopia are discussed en
dc.language English en
dc.subject Protozoal diseases en
dc.subject Malaria en
dc.subject Plasmodium falciparum en
dc.subject Vectors en
dc.subject Mosquitoes en
dc.subject Anopheles arabiensis en
dc.subject Screening en
dc.subject kdr en
dc.subject Alleles en
dc.subject Frequency en
dc.subject Polymerase chain reaction en
dc.subject PCR en
dc.subject Mutations en
dc.subject DNA extraction en
dc.subject Mortality rates en
dc.subject Knockdown resistance en
dc.subject Ethiopia en
dc.subject Africa, East en
dc.title First evidence of high knockdown resistance frequency in Anopheles arabiensis (Diptera: Culicidae) from Ethiopia en
dc.type Article en
dc.citation.issue 1 en
dc.citation.jtitle American Journal of Tropical Medicine and Hygiene en
dc.citation.volume 83 en
dc.citation.pages 122-125 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/20595490
dc.citation.jabbreviation Am J Trop Med Hyg en


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