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Spatial analysis of Leishmania donovani exposure in humans and domestic animals in a recent kala azar focus in Nepal

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dc.contributor.author Khanal, B.
dc.contributor.author Picado, A.
dc.contributor.author Bhattarai, N. R.
dc.contributor.author Van der Auwera, G.
dc.contributor.author Das, M. L.
dc.contributor.author Ostyn, B.
dc.contributor.author Davies, C. R.
dc.contributor.author Boelaert, M.
dc.contributor.author Dujardin, J. C.
dc.contributor.author Rijal, S.
dc.date.accessioned 2010-10-05T12:37:00Z
dc.date.available 2010-10-05T12:37:00Z
dc.date.issued 2010
dc.identifier.issn 0031-1820
dc.identifier.doi http://dx.doi.org/10.1017/S0031182010000521
dc.identifier.other ITG-P3B
dc.identifier.other ITG-P4B
dc.identifier.other ITG-H6B
dc.identifier.other ITG-H8A
dc.identifier.other ITG-P9A
dc.identifier.other MULTI
dc.identifier.other PARAS
dc.identifier.other U-PROTO
dc.identifier.other HEALTH
dc.identifier.other U-EPID
dc.identifier.other JIF
dc.identifier.other DOI
dc.identifier.other UPD25
dc.identifier.other FTA
dc.identifier.uri http://hdl.handle.net/10390/6297
dc.description.abstract SUMMARY Visceral leishmaniasis (VL) is a major public health problem in the Indian subcontinent where the Leishmania donovani transmission cycle is described as anthroponotic. However, the role of animals (in particular domestic animals) in the persistence and expansion of VL is still a matter of debate. We combined Direct Agglutination Test (DAT) results in humans and domestic animals with Geographic Information System technology (i.e. extraction maps and scan statistic) to evaluate the exposure to L. donovani on these 2 populations in a recent VL focus in Nepal. A Poisson regression model was used to assess the risk of infection in humans associated with, among other factors, the proportion of DAT-positive animals in the proximities of the household. The serological results showed that both humans and domestic animals were exposed to L. donovani. DAT-positive animals and humans were spatially clustered. The presence of serologically positive goats (IRR=9.71), past VL cases (IRR=2.62) and the proximity to a forest island dividing the study area (IRR=3.67) increased the risk of being DAT-positive in humans. Even if they are not a reservoir, domestic animals, and specially goats, may play a role in the distribution of L. donovani, in particular in this new VL focus en
dc.language English en
dc.subject Protozoal diseases en
dc.subject Leishmaniasis en
dc.subject Visceral en
dc.subject Kala azar en
dc.subject Leishmania donovani en
dc.subject Vectors en
dc.subject Phlebotomus argentipes en
dc.subject Sandflies en
dc.subject Reservoirs en
dc.subject Domestic animals en
dc.subject Buffaloes en
dc.subject Cattle en
dc.subject Goats en
dc.subject Disease transmission en
dc.subject Transmission dynamics en
dc.subject Exposure en
dc.subject Detection en
dc.subject Direct agglutination test en
dc.subject DAT en
dc.subject Risk assessment en
dc.subject Risk factors en
dc.subject Nepal en
dc.subject Asia, South en
dc.title Spatial analysis of Leishmania donovani exposure in humans and domestic animals in a recent kala azar focus in Nepal en
dc.type Article en
dc.citation.issue 11 en
dc.citation.jtitle Parasitology en
dc.citation.volume 137 en
dc.citation.pages 1597-1603 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/20459877
dc.citation.jabbreviation Parasitology en


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