Institute of Tropical Medicine Antwerp
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Autopsy causes of death in HIV-positive individuals in sub-Saharan Africa and correlation with clinical diagnoses

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dc.contributor.author Cox, J. A.
dc.contributor.author Lukande, R. L.
dc.contributor.author Lucas, S.
dc.contributor.author Nelson, A. M.
dc.contributor.author Van Marck, E.
dc.contributor.author Colebunders, R.
dc.date.accessioned 2011-01-06T10:24:32Z
dc.date.available 2011-01-06T10:24:32Z
dc.date.issued 2010
dc.identifier.issn 1139-6121
dc.identifier.other ITG-C1B
dc.identifier.other ITG-CLA
dc.identifier.other CLINIC
dc.identifier.other U-HIVCLI
dc.identifier.other JIF
dc.identifier.other Abstract
dc.identifier.other UPD29
dc.identifier.uri http://hdl.handle.net/10390/6416
dc.description.abstract Despite the persistently high HIV-related mortality in sub-Saharan Africa, limited information on the causes of death is available. Pathological autopsies are the gold standard to establish causes of death. In this review we describe the autopsy series performed among HIV-infected individuals in sub-Saharan Africa over the last two decades. We identified nine complete and 11 partial or minimally invasive autopsy series. Complete autopsies were performed in 593 HIV-positive adults and 177 HIV-positive children. Postmortem diagnoses were mainly infectious diseases. Tuberculosis was the most frequent, present in 21-54% of HIV-positive adults and was considered the cause of death in 32-45%. Overall, pulmonary infections accounted for approximately 66% of pathology and central nervous system infections for approximately 20%. A high discordance between clinical and postmortem diagnoses was observed. This review emphasizes the need for reliable information on causes of death in order to improve HIV patient care, guide further research, and inform health policy. en
dc.language English en
dc.subject Viral diseases en
dc.subject HIV en
dc.subject AIDS en
dc.subject Mortality en
dc.subject Autopsy en
dc.subject Adults en
dc.subject Children en
dc.subject Clinical diagnosis en
dc.subject Causes of death en
dc.subject Tuberculosis en
dc.subject Pulmonary diseases en
dc.subject Central nervous system en
dc.subject Discordance en
dc.subject Correlation en
dc.subject Review of the literature en
dc.subject Africa, General en
dc.title Autopsy causes of death in HIV-positive individuals in sub-Saharan Africa and correlation with clinical diagnoses en
dc.type Article en
dc.citation.issue 4 en
dc.citation.jtitle AIDS Reviews en
dc.citation.volume 12 en
dc.citation.pages 183-194 en
dc.identifier.pmid http://www.ncbi.nlm.nih.gov/pubmed/21179183
dc.citation.jabbreviation AIDS Rev en


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